Design of a prolonged release matrix system based on chitosan of Chilean production DISENO DE UN SISTEMA MATRIZ DE LIBERACION PROLONGADA A BASE DE QUITOSANO DE PRODUCCION CHILENA
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The objectives of this work were to establish the utility of chitosan of Chilean production, as an excipient suitable for producing a prolonged-release hydrophilic matrix, and to compare two matrix systems, one with chitosan (Q) and the other with the mixture chitosan-alginate (Q/A).The formulations (Q/A) produced a more prolonged drug release than formulations (Q). Formulations B (Q 20%), C (Q 30%), and D (Q/A 10%) showed a mechanism of release controlled by fickian diffusion. Formulations E (Q/A 20%) and F (Q/A 30%) showed a non-fickian diffusion. The thermodynamic activation parameters calculated for formulations C and D showed similar dG values.
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