Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
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2014Metadata
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Ocaranza, Maria Paz
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Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Author
- Ocaranza, Maria Paz;
- Moya, Jackeline;
- Barrientos, Victor;
- Alzamora, Rodrigo;
- Hevia, Daniel;
- Morales, Cristobal;
- Pinto, Melissa;
- Escudero, Nicolás;
- García Nannig, Lorena;
- Novoa, Ulises;
- Ayala, Pedro;
- Díaz Araya, Guillermo;
- Godoy, Ivan;
- Chiong Lay, Mario;
- Lavandero González, Sergio;
- Jalil Milad, Jorge;
Abstract
BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: In this study, we evaluated whether angiotensin-(1-9) decreases hypertension and reverses experimental cardiovascular damage in the rat. METHODS AND RESULTS:: Angiotensin-(1-9) (600 ng/kg per min for 2 weeks) reduced already-established hypertension in rats with early high blood pressure induced by angiotensin II infusion or renal artery clipping. Angiotensin-(1-9) also improved cardiac (assessed by echocardiography) and endothelial function in small-diameter mesenteric arteries, cardiac and aortic wall hypertrophy, fibrosis, oxidative stress, collagen and transforming growth factor type β - 1 protein expression (assessed by western blot). The beneficial effect of angiotensin-(1-9) was blunted by coadministration of the angiotensin type 2(AT2) receptor blocker PD123319
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Identifier
URI: https://repositorio.uchile.cl/handle/2250/158312
DOI: 10.1097/HJH.0000000000000094
ISSN: 14735598
02636352
Quote Item
Journal of Hypertension, Volumen 32, Issue 4, 2018, Pages 771-783
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