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Effect of aging on biliary lipid composition and bile acid metabolism in normal chilean women

Authordc.contributor.authorValdivieso, Vicente 
Authordc.contributor.authorPalma, Renato 
Authordc.contributor.authorWünkhaus, Raúl 
Authordc.contributor.authorAntezana, Cristina 
Authordc.contributor.authorSeverín, Cecilia 
Authordc.contributor.authorContreras, Alicia 
Cita de ítemdc.identifier.citationGastroenterology, Volumen 74, Issue 5 PART 1, 2018, Pages 871-874
Abstractdc.description.abstractBiliary lipid composition was determined in fasting gallbladder bile of 12 young and 12 elderly asymptomatic Chilean women with normal weights and recent, normal cholecystograms. The proportion of biliary cholesterol and the lithogenic index were significantly higher in elderly females. Moreover, supersaturated bile was present in 8.3% of the young and in 41.7% of the older women studied. Obesity enhances the saturation of bile in older females: lithogenic bile was found in 100% of 4 elderly, obese women with radiologically normal gallbladders. The bile acid pool and cholic acid metabolism were studied in 5 young and 4 older normal females. Both groups showed similar values of bile acid pool, cholic acid synthesis, and turnover. These results indicate that aging per se modifies the proportions of biliary lipids in Chilean women, and provide a partial explanation for the frequency of gallstones observed among them. The increment in the lithogenic index of gallbladder bile with age takes
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
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Títulodc.titleEffect of aging on biliary lipid composition and bile acid metabolism in normal chilean women
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile