Synthesis of hybrid copper-chitosan nanoparticles with antibacterial activity against cariogenic Streptococcus mutans
Author
dc.contributor.author
Covarrubias Gallardo, Cristián
Author
dc.contributor.author
Trepiana Fica, Diego Andrés
Author
dc.contributor.author
Corral Núñez, Camila
Admission date
dc.date.accessioned
2018-12-27T19:38:14Z
Available date
dc.date.available
2018-12-27T19:38:14Z
Publication date
dc.date.issued
2018-06
Cita de ítem
dc.identifier.citation
Dental Materials Journal 2018; 37(3); 379-384 p.
es_ES
Identifier
dc.identifier.issn
0287-4547
Identifier
dc.identifier.other
10.4012/dmj.2017-195
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/159231
Abstract
dc.description.abstract
Hybrid nanoparticles (CuChNP) comprising of copper nanoparticles with a chitosan shell were synthesized. Antimicrobial properties of CuChNP were assessed against Streptococcus mutans (S. mutans), one of the main bacterium that causes tooth decay. Antibacterial activity of CuChNP against S. mutans was comparable to that of oral antimicrobial agents, such as chlorhexidine, and cetylpyridinium chloride. Particularly, CuChNP exhibited superior capacity to prevent the S. mutans growth on human tooth surface as well as disrupt and kill the bacterial cells in an established dental biofilm. Chitosan may interact with both tooth hydroxyapatite and bacterial cell wall, which improves the adherence of copper to the tooth surface and potentiates their anti-biofilm action. The antimicrobial properties exhibited by CuChNP could be useful for the future development of more effective treatments for the control of dental plaque biofilms.