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Mandibular bone loss after masticatory muscles intervention with botulinum toxin: An approach from basic research to clinical findings

Authordc.contributor.authorBalanta Melo, Julián 
Authordc.contributor.authorToro Ibacache, Viviana 
Authordc.contributor.authorKupczik, Kornelius 
Authordc.contributor.authorBuvinic, Sonja 
Cita de ítemdc.identifier.citationToxins, Volumen 11, Issue 2, 2019,
Abstractdc.description.abstractThe injection of botulinum toxin type A (BoNT/A) in the masticatory muscles, to cause its temporary paralysis, is a widely used intervention for clinical disorders such as oromandibular dystonia, sleep bruxism, and aesthetics (i.e., masseteric hypertrophy). Considering that muscle contraction is required for mechano-transduction to maintain bone homeostasis, it is relevant to address the bone adverse effects associated with muscle condition after this intervention. Our aim is to condense the current and relevant literature about mandibular bone loss in fully mature mammals after BoNT/A intervention in the masticatory muscles. Here, we compile evidence from animal models (mice, rats, and rabbits) to clinical studies, demonstrating that BoNT/A-induced masticatory muscle atrophy promotes mandibular bone loss. Mandibular bone-related adverse effects involve cellular and metabolic changes, microstructure degradation, and morphological alterations. While bone loss has
Publisherdc.publisherMDPI AG
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Keywordsdc.subjectAlveolar bone loss
Keywordsdc.subjectAlveolar process
Keywordsdc.subjectBone quality
Keywordsdc.subjectBotulinum toxin type a
Keywordsdc.subjectMandibular condyle
Keywordsdc.subjectMuscle atrophy
Keywordsdc.subjectTemporomandibular joint
Títulodc.titleMandibular bone loss after masticatory muscles intervention with botulinum toxin: An approach from basic research to clinical findings
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile