Neurocognitive mechanisms underlying working memory encoding and retrieval in Attention-Deficit/Hyperactivity Disorder
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Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retain information rather than on the attention-dependent stages of encoding and retrieval. The current study uses a visual short-term memory binding task, measuring both behavioral and electrophysiological responses to characterize WM encoding, binding and retrieval comparing ADHD and non-ADHD matched adolescents. ADHD exhibited poorer accuracy and larger reaction times than non-ADHD on all conditions but especially when a change across encoding and test displays occurred. Binding manipulation affected equally both groups. Encoding P3 was larger in the non-ADHD group. Retrieval P3 discriminated change only in the non-ADHD group. Binding-dependent ERP modulations did not reveal group differences. Encoding and retrieval P3 were significantly correlated only in non-ADHD. These results suggest that while binding processes seem to be intact in ADHD, attention-related encoding and retrieval processes are compromised, resulting in a failure in the prioritization of relevant information. This new evidence can also inform recent theories of binding in visual WM.
postdoctoral grant CONICYT/FONDECYT 3150195 CONICYT PAI/Concurso Nacional Insercion de Capital Humano Avanzado en la Academia Convocatoria ano 2017 PAI79170011 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1160258 1150241 Alzheimer's Society AS-R42303 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) Programa Interdisciplinario de Investigacion Experimental en Comunicacion y Cognicion (PIIECC), Facultad de Humanidades, USACH
Artículo de publicación ISI
Quote ItemScientific Reports (2020) 10:7771
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