Early pregnancy levels of gingival crevicular fluid matrix metalloproteinases-8 and −9 are associated with the severity of periodontitis and the development of gestational diabetes mellitus
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Background Gestational diabetes mellitus (GDM) is increasing worldwide and women with a history of GDM are at risk of developing type 2 diabetes which is a risk factor for periodontitis. Aim To explore the association between the concentrations of matrix metalloproteinase (MMP)-8 and -9 in gingival crevicular fluid (GCF) during early pregnancy with the periodontal diagnosis and the risk of GDM development. Materials and methods A prospective cohort study, including 314 women, enrolled at 11 to 14 weeks of pregnancy was conducted. A complete maternal/obstetric and periodontal exam was performed, and GCF samples were obtained for the MMP-8 and -9 determination by Multiplex Elisa Assays. Mann-Whitney test; Spearman's correlation and log-binomial regression model estimated the association between MMPs concentration in GCF and GDM. Results Fourteen percent of the pregnancies were diagnosed with GDM. An increase in the concentration of MMP-8 and -9 in women with periodontitis stage III and IV compared to periodontitis stage I was observed (99.31 ng/mL [IQR: 85.32] versus 71.95 ng/mL [IQR: 54.04], and 262.4 ng/mL [IQR: 312.55] versus 114.1 ng/mL [IQR: 184.94], respectively). Women who developed GDM showed increased concentrations of MMP-8 and -9 in GCF since the beginning of pregnancy (P = 0.0381;P = 0.0302, respectively). MMP-8 concentration in GCF was associated with GDM (RR: 1.19;P = 0.045; CI 95% 1.00 to 1.40; and RR: 1.20;P = 0.063; CI 95% 0.99 to 1.45 in the adjusted model). Conclusion(s) GCF concentrations of MMP-8 and -9 at early of pregnancy are increased in women with severe periodontitis and associated with the GDM development.
FONDEFIDeA, Fund to Encourage Scientific and Technological Development ("FONDEF") ID16I10452 Helsinki University Hospital TYH2016251 TYH2017251 TYH2018229 TYH2019319 Y1014SLO17 Y1014SLO18 Y1014SULE1 Karolinska Institutet, Stockholm, Sweden
Artículo de publicación ISI
Quote ItemJ Periodontol. 2020;1–11.
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