Browsing by Author "XX598337"
Now showing items 1-20 of 44
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(Frontiers Media, 2020)Background Vitamin K antagonists (VKA) are used as prophylaxis for thromboembolic events in patients with cardiovascular diseases. The most common VKA are warfarin and acenocoumarol. These drugs have a narrow therapeutic ...
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(Lippicott Williams & Wilkins, 2016-04)
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(Elsevier Ltd, 2018)© 2018 Elsevier Ltd This study assessed the effects of polymorphic variants of gutathione-S-transferase and metallothioneins on profiles of urinary arsenic species. Drinking groundwater from Margarita and San Fernando, ...
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(2010)Los avances en farmacología clínica muestran que la edad afecta considerablemente la farmacocinética de los medicamentos, por lo tanto, sus efectos en lactantes y niños pueden diferir a los producidos en adultos, aún cuando ...
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(Springer Science, 2009)Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the ...
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(2009)Olanzapina es un nuevo antipsicótico tienobenzodiazepínico estructuralmente relacionado con clozapina. Esta droga ha demostrado gran eficacia en el tratamiento de pacientes esquizofrénicos, con baja incidencia de efectos ...
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(Elsevier, 2015)We tested the influence of four polymorphisms and gene duplication in CYP2D6 on in vivo enzyme activity in a Chilean mestizo population in order to identify the most relevant genetic profiles that account for observed ...
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(Elsevier, 2015-11)We tested the influence of four polymorphisms and gene duplication in CYP2D6 on in vivo enzyme activity in a Chilean mestizo population in order to identify the most relevant genetic profiles that account for observed ...
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(1997-03)Estudio preliminar realizado en Temuco demuestra que el problema de la contaminación atmosférica en Chile no es privativo de la ciudad de Santiago. Los resultados de las mediciones arrojaron alta concentración de ...
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(2006)Background: Gastric cancer (GaC) is the second cause of death by cancer in the world and one of the first causes in Chile. However, the burden of this disease shows remarkable worldwide variation probably explained by ...
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(Universidad de Chile, 2010-03)El ser humano está constantemente expuesto a agentes externos (xenobióticos), entre los que se incluyen los fármacos. La mayoría de estos xenobióticos son lipofílicos siendo absorbidos por la mucosa gastrointestinal hacia ...
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(2011-12)Antecedentes: La mayoría de los pacientes que reciben tratamientos con anticoagulantes orales por periodos prolongados presentan variabilidad en la respuesta. El acenocumarol es el anticoagulante oral más prescrito en ...
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(2002)
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(2011)En el presente trabajo se hace un análisis de los conceptos, normativas y propuestas sobre la equivalencia terapéutica de medicamentos similares con respecto a los innovadores, desde una perspectiva internacional y nacional, ...
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(2002)El objeto de esta exposición es analizar un factor genético que se está postulando como posible causa, al menos en parte, de la esteatohepatitis no alcohólica y alcohólica: el denominado gen CYP2E1, que pertenece a la ...
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(2012)Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are ...
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(SAGE, 2020)Despite the development of new oral agents over the last decade, vitamin K antagonists (VKAs) remain the most widely used anticoagulants for treating and preventing thromboembolism worldwide. In Chile, the Ministry of ...
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(Nova Science, 2017)The ultimate goal of pharmacogenomic research is to predict individual's responses to drug therapy and subsequently adapt pharmacotherapeutic strategies. Therefore, the current challenge for personalized therapy is to ...
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(2016)Acute lymphoblastic leukemia (ALL) is a frequent neoplasia occurring in children. The most commonly used drug for the treatment of ALL is methotrexate (MTX), an anti-folate agent. Previous studies suggest that folate ...
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(1997)1. Respirable, airborne particles in the ambient air in downtown Santiago, Chile, have been characterized for the seasonal variation in total polycyclic aromatic hydrocarbon content, 13 of which have been identi® ed ...
