Browsing by Author "XX676228"

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    • Association between P53 codon 72 genetic polymorphism and tobacco use and lung cancer risk 
      Cáceres Lillo, Dante; Quiñones Sepúlveda, Luis; Schroeder, Jane C.; Gil, Leonel D.; Irarrázabal, Carlos C. (Springer Science, 2009)
      Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the ...
    • BIODISPONIBILIDAD RELATIVA DE UNA FORMULACION ORAL DE OLANZAPINA DEL MERCADO NACIONAL, RESPECTO A LA ... 
      Saavedra Saavedra, Iván; Alarcón, Alejandra; Bustamante Valdebenito, Rodrigo; Cáceres Lillo, Dante; Letelier Muñoz, María Eugenia; Quiñones Sepúlveda, Luis (2009)
      Olanzapina es un nuevo antipsicótico tienobenzodiazepínico estructuralmente relacionado con clozapina. Esta droga ha demostrado gran eficacia en el tratamiento de pacientes esquizofrénicos, con baja incidencia de efectos ...
    • Bioequivalence of Acenocoumarol in Chilean Volunteers: an Open, Randomized, Double-Blind, Single-Dose, ... 
      Sasso Aguirre, Jaime Alfredo; Carmona, P.; Quiñones Sepúlveda, Luis; Ortiz Olcay, Mario; Tamayo Carrillo, Evelyn; Varela Figueroa, Nelson; Cáceres Lillo, Dante; Saavedra Saavedra, Iván (2012)
      The aim of this study was to compare the bioavailability of an oral formulation of the coumarin derivative-vitamine K antagonist acenocoumarol (Acebron TM 4 mg, Test) with the reference formulation (Neo-Sintrom TM 4 ...
    • Caracterización epidemiológica de mordeduras en personas, según registro de atención de urgencia. Provincia ... 
      Villagra, Vania; Cáceres Lillo, Dante; Alvarado Orellana, Sergio; Salinas, Elizabeth; Caldera, M. Loreto; Lucero, Erick; Viviani, Paola; Torres, Marisa (Sociedad Chilena de Infectología, 2017)
      Background: Bites constitute a public health problem worldwide. Aim: To characterize epidemiologically bites by animals happened in the province of Los Andes (2005-2007). Method: Descriptive, retrospective epidemiological ...
    • Contaminación del aire en espacios exteriores e interiores en la ciudad de Temuco 
      Gil, Lionel; Cáceres Lillo, Dante; Quiñones Sepúlveda, Luis; Adonis Parraguez, Marta (1997-03)
      Estudio preliminar realizado en Temuco demuestra que el problema de la contaminación atmosférica en Chile no es privativo de la ciudad de Santiago. Los resultados de las mediciones arrojaron alta concentración de ...
    • Contribution of Anthropogenic Factors and Climate Variables to Human Cystic Echinococcosis Mortality in ... 
      Martínez Gallegos, Paulina; Canals Lambarri, Mauricio; Alvarado Orellana, Sergio; Cáceres Lillo, Dante (Mary Ann Liebert, 2020)
      Here we assess the effect of weather and anthropogenic environmental variables, particularly urbanization, on cystic echinococcosis mortality in Chile from 2001 to 2011 using a nonparametric regression model, multivariate ...
    • CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer ... 
      Quiñones Sepúlveda, Luis; Lucas, D.; Godoy, J.; Cáceres Lillo, Dante; Berthou, F.; Varela Figueroa, Nelson; Lee, K.; Acevedo, C.; Martínez, L.; Aguilera, A. M.; Gil, Lionel (Elsevier, 2001)
      CYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val ...
    • Determinación del polimorfismo de CYP2C9*2 y su relación con la farmacocinética de acenocumarol en voluntarios ... 
      Miranda, Carla; Roco, Ángela; Garay, Joselyn; Squicciarini, Valentina; Tamayo Carrillo, Evelyn; Agúndez, José; García Martin, Elena; Sasso Aguirre, Jaime Alfredo; Saavedra Saavedra, Iván; Cáceres Lillo, Dante; Quiñones Sepúlveda, Luis (2011-12)
      Antecedentes: La mayoría de los pacientes que reciben tratamientos con anticoagulantes orales por periodos prolongados presentan variabilidad en la respuesta. El acenocumarol es el anticoagulante oral más prescrito en ...
    • Development of a small panel of SNPs to infer ancestry in chileans that distinguishes Aymara and Mapuche components 
      Verdugo Salgado, Ricardo; Di Genova, Alex; Herrera Cisterna, Luisa; Moraga Vergara, Mauricio; Acuña Patzke, Mónica; Berríos del Solar, María Soledad; Llop Romero, Elena; Valenzuela, Carlos Y.; Bustamante Calderón, María Leonor; Digman, Dayhana; Symon Maturana, Adriana; Asenjo, Soledad; López Contreras, Pamela; Blanco, Alejandro E.; Suazo Sanhueza, José; Barozet, Emmanuelle; Caba, Fresia; Villalón Calderón, Marcelo; Alvarado Orellana, Sergio; Cáceres Lillo, Dante; Salgado, Katherine; Portales, Pilar; Moreno Estrada, Andrés; Gignoux, Christopher; Sandoval, Karla; Bustamante, Carlos; Eng, Celeste; Huntsman, Scott; Burchard, Esteban; Loira, Nicolás; Maass Sepúlveda, Alejandro; Cifuentes Ovalle, Lucía (Sociedad de Biología de Chile, 2020)
      Background Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may ...
    • Early tobacco and alcohol consumption as modifying risk factors on marijuana use 
      Iglesias Álamos, Verónica; Cavada Chacón, Gabriel; Silva, Claudio; Cáceres Lillo, Dante (2007)
      OBJECTIVE: To. assess the relationship between early tobacco and alcohol use and the risk of marijuana consumption among schoolchildren. METHODS: A cross-sectional study comprising data from the Fourth National Study on ...
    • Exposure to inorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean population 
      Cáceres Lillo, Dante; Pino Zúñiga, Paulina; Montesinos Belmar, Néstor; Atalah Samur, Eduardo; Amigo Cartagena, Hugo; Loomis, Dana (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-06)
      The relationship of inorganic arsenic exposure through drinking water and total urinary arsenic excretion in a nonoccupationally exposed population was evaluated in a cross-sectional study in three mayor cities of Chile ...
    • Farmacogenética del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer ... 
      Quiñones Sepúlveda, Luis; Lee, Kuen; Varela Figueroa, Nelson; Escala, Mario; García, Karen; Godoy, Loreto; Castro, Andrés; Soto Labbé, Jorge; Saavedra Saavedra, Iván; Cáceres Lillo, Dante (2006)
      Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development ...
    • Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs ... 
      Roco Arriagada, Angela Margarita; Quiñones Sepúlveda, Luis; Agúndez, José A. G.; García Martin, Elena; Squicciarini Rueda, Valentina; Miranda Melo, Carla Estefanía; Garay, Joselyn; Farfán, Nancy; Saavedra Saavedra, Iván; Cáceres Lillo, Dante; Ibarra, Carol; Varela Figueroa, Nelson (2012)
      Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are ...
    • Genetic polymorphisms as non-modifiable susceptibility factors to laryngeal cancer 
      Escalante, Paula; Barría, Tamara; Cancino Castañeda, Miguel; Rahal Espejo, Maritza; Cerpa, Leslie; Sandoval, Christopher; Molina Mellico, Sebastián; Suárez, Marcelo I.; Martínez, Matías; Cáceres Lillo, Dante; Quiñones, Luis Abel; Varela Figueroa, Nelson (Portland Press, 2020)
      Laryngeal squamous cell carcinoma (LSCC) is a highly disabling disease to the patient, affecting speech, swallowing and respiratory skills. Smoking and alcohol abuse are principal risk factors linked to this disease. Genetic ...
    • Identification of daily environmental noise patterns in two different urban sites in Santiago, Chile 
      Fuentes Alburquenque, Mauricio; Marzzano Ríos, Antonio; Canals Lambarri, Mauricio; Torres Arellano, Rodrigo; Cáceres Lillo, Dante; Alvarado Orellana, Sergio (Sociedad Médica Santiago, 2020)
      Background: Environmental noise can cause auditory and non-auditory adverse effects. Aim: To identify daily environmental noise patterns in two urban sites of Metropolitan Santiago. Material and Methods: Continuous ...
    • Influence of CYP3A4/5 Polymorphisms in the pharmaconetics of levonorgestrel: a pilot study 
      Moreno, Iván; Quiñones Sepúlveda, Luis; Catalán, Johanna; Miranda Melo, Carla Estefanía; Roco Arriagada, Ángela Margarita; Sasso Aguirre, Jaime Alfredo; Tamayo Carrillo, Evelyn; Cáceres Lillo, Dante; Tchernitchin Varlamov, Andrés; Gaete González, Leonardo; Saavedra Saavedra, Iván (2012)
      Introduction. Levonorgestrel a synthetic progestagen used for endometriosis, dysmenorrhea and emergency contraception, is quickly and completely absorbed in the digestive tract. levonorgestrel is predominantly metabolised ...
    • Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an ... 
      Quiñones Sepúlveda, Luis; Irarrázabal, Carlos E.; Rojas, Claudio R.; Orellana, Cristián E.; Acevedo Castillo, Cristián; Huidobro Alvarado, Christian; Varela, Nelson E.; Cáceres Lillo, Dante (BLACKWELL, 2006-05)
      Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the ...
    • Papel de las enzimas citocromo p450 en el metabolismo de fármacos antineoplásicos: Situación actual y ... 
      Quiñones Sepúlveda, Luis; Rosero P., Mario; Roco Arriagada, Angela Margarita; Moreno T., Iván; Sasso Aguirre, Jaime Alfredo; Varela Figueroa, Nelson; Cáceres Lillo, Dante; Saavedra Saavedra, Iván (Sociedad Médica de Santiago, 2008-10)
      Cytochrome P450 enzymes are very important to metabolize anti-carcinogenic agents. Therefore, understanding the role of these enzymes and their allele variants in the bioactivation or detoxification of drugs could greatiy ...
    • Polymorphism of Glutathione S-Transferase (GST) Variants and Its Effect on Distribution of Urinary Arsenic ... 
      Cáceres Lillo, Dante; Werlinger Cruces, Fabiola; Orellana, Magdalena; Jara, Marcelo; Rocha, René; Alvarado, Sergio A.; Quiñones Sepúlveda, Luis (Taylor & Francis, 2013-07-09)
      Glutathione S-tranferases (GST) are multigenic enzymes that have been associated with arsenic metabolism. The objective of this study was to evaluate the relationship between polymorphic variants of GST and urinary ...
    • Prevalencia de la infección por Helicobacter pylori según ensayo de la ureasa en pacientes derivados a la ... 
      Toledo Araya, Héctor; Defilippi Cafri, Carlos; Madrid Silva, Ana; Defilippi Guerra, Claudia; Vallejos M., Cristián; Cáceres Lillo, Dante; Venegas Santos, Mauricio (2007)
      Background: Helicobacter pylori is a pathogenic bacterium that infects a significant number of individuals. In Chile about 79% of the population is colonized. Aims: This study evaluate the prevalence of the H. pylori ...