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Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study

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2006-05
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Quiñones Sepúlveda, Luis
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Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study
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Author
  • Quiñones Sepúlveda, Luis;
  • Irarrázabal, Carlos E.;
  • Rojas, Claudio R.;
  • Orellana, Cristián E.;
  • Acevedo Castillo, Cristián;
  • Huidobro Alvarado, Christian;
  • Varela, Nelson E.;
  • Cáceres Lillo, Dante;
Abstract
Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. Methods: In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. Results: The joint risk for smokers carrying Pro* and M1*, Pro* and GSTM1null or GSTM1 null and CYP1A1 M1* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% Cl: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M I in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the Putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71). Conclusion: Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.
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URI: https://repositorio.uchile.cl/handle/2250/127924
ISSN: 1008-682X
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ASIAN JOURNAL OF ANDROLOGY Volume: 8 Issue: 3 Pages: 349-355 Published: MAY 2006
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