Browsing by Title

Now showing items 50520-50539 of 93218

    • Inhibición in vivo de las caspasas y su efecto en la apoptosis y espermatogénesis de la rata 
      Codelia Arce, Verónica Andrea. (Universidad de Chile, 2007)
      La espermatogénesis es un proceso complejo a través del cual se forman espermatozoides haploides a partir de espermatogonias diploides. Varios estudios indican que un desbalance en los factores que controlan la muerte ...
    • Inhibición inducida por odorantes en neuronas olfatorias de caudiverbera caudiverbera 
      Morales Muñoz, Bernardo Enrique (Universidad de Chile, 1995)
    • El inhibidor de rock, fasudil y el antidepresivo sertralina comparten efectos a nivel morfológico y molecular ... 
      García Rojo, Gonzalo Javier (Universidad de Chile, 2017)
      La depresión es un trastorno psiquiátrico muy prevalente en Chile y el mundo. Sus bases moleculares son prácticamente desconocidas, por lo que los tratamientos farmacológicos no han logrado ser del todo efectivos. En la ...
    • Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells 
      Mamo, Tewodros; Mladek, Ann C.; Shogren, Kris L.; Gustafson, Carl; Gupta, Shiv K.; Riester, Scott M.; Maran, Avudaiappan; Galindo, Mario A.; van Wijnen, Andre J.; Sarkaria, Jann N.; Yaszemski, Michael J. (Elsevier B.V., 2017)
      © 2017 Elsevier Inc. Osteosarcoma survival rate has not improved over the past three decades, and the debilitating side effects of the surgical treatment suggest the need for alternative local control approaches. Radiotherapy ...
    • Inhibiting Pathogen Surface Adherence by Multilayer Polyelectrolyte Films Functionalized with Glucofuranose ... 
      Villalobos, Valeria; Leiva, Ángel; Ríos, Hernán E.; Pavez, Jorge; Silva, Carlos P.; Ahmar, Mohammed; Queneau, Yves; Blamey, J. M.; Chávez, Francisco P.; Urzúa Acevedo, Marcela (American Chemical Society, 2018)
      © 2018 American Chemical Society. Inhibiting pathogenic bacterial adherence on surfaces is an ongoing challenge to prevent the development of biofilms. Multilayer polyelectrolyte films are feasible antibacterial materials. ...
    • Inhibition and activation of UDP-glucuronyltransferase in alloxanic-diabetic rats 
      Vega, Patricio; Gaule, Carlos; Sanchez, Emilio; Villar, Eugenia del (1986)
      Short or long term alloxan diabetes produced activation of oestrone and morphine glucuronidation and inhibition of p-nitrophenol glucuronidation in rat liver microsomes. Insulin treatment restored decreased glucuronyltransferase ...
    • Inhibition by phenothiazine derivatives of the adenylate cyclase of amphibian oocytes 
      Olate, Juan; Jordana, Xavier; Allende, Catherine C.; Allende, Jorge E. (1983)
      The adenylate cyclase activity of membranes of Xenopus laevis oocytes and follicle cells was affected by the presence of 2-chloro-10-(3-aminopropyl)phenothiazine (CAPP) and two other antipsychotic drugs, fluphenazine and ...
    • Inhibition of ATPase from chloroplasts by a hydroxamic acid from the gramineae 
      Queirolo, Carlos B.; Andreo, Carlos S.; Niemeyer Marich, August; Corcuera, Luis J. (1983)
      -DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one), a hydroxamic acid from the Gramineae involved in the resistance of cereals to aphids, inhibits. © 1983.
    • Inhibition of autophagy by TAB2 and TAB3 
      Criollo Céspedes, Alfredo; Niso-Santano, Mireia; Malik, Shoaib Ahmad; Michaud, Mickael; Morselli, Eugenia; Mariño, Guillermo; Lachkar, Sylvie; Arkhipenko, Alexander V.; Harper, Francis; Pierron, Gérard; Rain, Jean Christophe; Ninomiya-Tsuji, Jun; Fuentes, José M.; Lavandero González, Sergio (2011)
      Autophagic responses are coupled to the activation of the inhibitor of NF-κB kinase (IKK). Here, we report that the essential autophagy mediator Beclin 1 and TGFβ-activated kinase 1 (TAK1)-binding proteins 2 and 3 (TAB2 ...
    • Inhibition of basal JNK activity by small interfering RNAs enhances cisplatin sensitivity and decreases DNA ... 
      Parra, Eduardo; Gutiérrez, Luis; Ferreira, Jorge (Spandidos Publications, 2015)
      Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in ...
    • Inhibition of beta-amyloid Aggregation of Ugni molinae Extracts 
      Jara Moreno, Daniela; Riveros Salvatierra, Ana L.; Barriga G., Andrés; Kogan, Marcelo J.; Delporte Vergara, Carla (Bentham Science Publishers, 2020)
      The beta-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the ...
    • Inhibition of cancer cell growth and migration by dihydroxynaphthyl aryl ketones 
      Benites, Julio; Valderrama, Jaime A.; Ríos, David; Lagos Mónaco, Rosalba; Monasterio Opazo, Octavio; Buc Calderón, Pedro (2016)
      Dihydroxynaphthyl aryl ketones 1-5 exhibit activity as tubulin polymerization inhibitors by targeting the colchicine binding site of microtubules making them potential anticancer drugs. Therefore, analogues 1-5 have been ...
    • Inhibition of cholinergic contractions of rat ileum by tropane-type alkaloids present in Schizanthus hookeri 
      Morales, Miguel A.; Ahumada, Frederick; Castillo, Erick; Burgos, Rafael; Christen, Philippe; Bustos, Viviana; Muñoz Muñoz, Orlando (Verlag der Zeitschrift fur Naturforschung, 2013)
      The relative lack of specificity of atropine as a competitive antagonist of muscarinic receptors is a frequent cause of undesirable parasympathetic side effects. Consequently, new tropane alkaloids with potentially greater ...
    • Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction ... 
      Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression 
      Morales, Cyndi R.; Li, Dan L.; Pedrozo Cibils, Zully; May, Herman I.; Jiang, Nan; Kyrychenko, Viktoriia; Cho, Geoffrey; Kim, Soo Young; Wang, Zhao V.; Rotter, David; Rothermel, Beverly A.; Schneider, Jay W.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Amer Assoc Advancement Science, 2016)
      Altering chromatin structure through histone posttranslational modifications has emerged as a key driver of transcriptional responses in cells. Modulation of these transcriptional responses by pharmacological inhibition ...
    • Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction ... 
      Maldonado, Horacio; Ramírez, Eugenio; Utreras Puratich, Elías; Pando, María E.; Kettlun, Ana M.; Chiong Lay, Mario; Kulkarni, Ashok B.; Collados, Lucía; Puente, Javier; Cartier Rovirosa, Luis; Valenzuela, María A. (2011)
      Human T-cell leukemia virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease characterized by selective loss of axons and myelin in the corticospinal tracts. This ...
    • Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper 
      Letelier Muñoz, María Eugenia; Martínez, M.; González Lira, Víctor; Faúndez, Mario; Aracena Parks, Paula (ELSEVIER, 2006-12-01)
      H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
    • Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour 
      Segura Aguilar, Juan; Díaz Véliz, Gabriela; Mora, S.; Herrera-Marschitz Muller, Mario (2002)
      Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
    • Inhibition of Egr-1 by siRNA in prostate carcinoma cell lines is associated with decreased expression of ... 
      Parra, Eduardo; Ferreira Parker, Jorge; Sáenz Iturriaga, Leonardo Enrique (2011)
      Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...
    • Inhibition of Egr-1 by siRNA in prostate carcinoma cell lines is associated with decreased expression of ... 
      Parra, Eduardo; Ferreira, Jorge; Sáenz Iturriaga, Leonardo Enrique (2011)
      Previous studies suggest that the effects of Egr-1 on tumorigenesis are critically dependent on the levels of Egr-1 and the cellular context. For this reason, we examined the effects of blocking the Egr-1 activity by a ...