Browsing by Author "Jalil Milad, Jorge"

Now showing items 1-20 of 37

    • Actividad plasmática de la enzima convertidora de angiotensina I en población chilena normal y relación con ... 
      Jalil Milad, Jorge; Córdova, Samuel; Piddo Mijares, Ana María; Chamorro, Gastón; Braun J., Sandra; Vega, Jeanette; Jadue, Liliana; Lavandero González, Sergio; Jalil R., R.; Lastra, P.; Garrido, Carmen (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2000)
      El objetivo del estudio fue estimar la prevalencia de los distintos alelos del polimorfismo del gen de la enzima convertidora de angiotensina (ECA), inserción/deserción (I/D) y simultáneamente la actividad de ECA plasmática ...
    • Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat ... 
      Ocaranza, María Paz; Piddo Mijares, Ana María; Faúndez Fuentes, Perla Andrea; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2002-03)
      Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
    • Angiotensin I-converting enzyme insertion/delection polymorphism and adrenergic response to exercise in ... 
      Jalil Milad, Jorge; Córdova, Samuel; Ocaranza, María Paz; Schumacher, Erwin; Braun J., Sandra; Chamorro, Gastón; Fardella, Carlos E.; Lavandero González, Sergio (International Medical Science for Experimental and Clinical Research, 2002)
      The insertion/delection ACE polymorphism (ACE I/D) regulates different levels of circulating and tissue ACE activities, which may induce diverse adrenergic responses to physiological stimuli. The aim of this study was ...
    • Angiotensin I-converting enzyme modulates neutral endopeptidase activity in the rat 
      Oliveri Pérez, Carla Giovanna; Ocaranza, María Paz; Campos Bastidas, Ximena; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2001-09)
      Angiotensin I is a substrate for both ACE and for neutral endopeptidase 24.11 (NEP). We hypothesized that high ACE expression is related to low NEP activity. Accordingly, circulating and tissue NEP and ACE activities were ...
    • Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin ... 
      Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolás; García Nannig, Lorena; Novoa, Ulises; Ayala, Pedro; Díaz Araya, Guillermo; Godoy, Ivan; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Lippincott Williams and Wilkins, 2014)
      BACKGROUND:: Little is known about the biological effects of angiotensin-(1-9), but available evidence shows that angiotensin-(1-9) has beneficial effects in preventing/ameliorating cardiovascular remodeling. OBJECTIVE:: ...
    • Blood pressure reduction, potassium channels, and the endothelium - Insights from L-serine 
      Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2008-03)
    • Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced ... 
      Copaja Soto, Miguel; Valenzuela, Rodrigo; Saldaña, Adiela; Ocaranza, María Paz; Jalil Milad, Jorge; Vio, Carlos; Lijnen, Paul; Ordenes, Gamaliel; Vivar Sánchez, Raúl; Lavandero González, Sergio; Díaz Araya, Guillermo (SAGE PUBLICATIONS LTD, 2008-09)
      Introduction. Isoproterenol treatment of Brown Norway Lewis rats (high and low plasma angiotersin-I-converting enzyme activity., respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown ...
    • Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin ... 
      Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)
      Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
    • Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme ... 
      Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)
      To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
    • Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat 
      Jalil Milad, Jorge; Ebensperger González, Roberto; Meléndez Vergara, Jaime; Acevedo, E.; Sapag Hagar, Mario; González Jara, Fabián Rodrigo; Gálvez, Anita; Pérez Montes, Viviana; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 1999-03-26)
      There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the ...
    • Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study 
      Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariángel, Víctor; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions 
      Garrido, Mauricio; Cárdenas, Angélica M.; Astorga, Jessica; Quinlan, Francisca; Valdés, Macarena; Chaparro, Alejandra; Carvajal, Paola; Pussinen, Pirkko; Huamán-Chipana, Patricia; Jalil Milad, Jorge; Hernández, Marcela (Elsevier Inc., 2019)
      Introduction: The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially high-sensitivity C-reactive protein (hsCRP), in young adults. ...
    • Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular ... 
      Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)
      The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ...
    • Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels 
      Jalil Milad, Jorge; Pérez, Alfonso; Ocaranza, María Paz; Bargetto, Jorge; Galaz, Alfonso; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2005-12)
      In humans and rats, angiotensin I-converting enzyme activity is significantly determined by a gene polymorphism. Homozygous Brown Norway rats have higher plasma angiotensin I-converting enzyme activity and circulating ...
    • Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary ... 
      Stehr, Carlos B.; Mellado, Rosemarie; Ocaranza, Maria P.; Carvajal, Cristian A.; Mosso, Lorena; Becerra, Elia; Solis, Margarita; García Nannig, Lorena; Lavandero González, Sergio; Jalil Milad, Jorge; Fardella, Carlos E. (2010)
      Background: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. ...
    • Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy 
      Gabrielli, Luigi A.; Winter, José L.; Godoy, Iván; McNab, Paul; Padilla, Ivonne; Córdova, Samuel; Rigotti, Paola; Novoa, Ulises; Mora, Italo; García Nannig, Lorena; Ocaranza, María P.; Jalil Milad, Jorge (Oxford University Press, 2014)
      background There is experimental evidence on the role of Rho-kinase (ROCK) activation in cardiac hypertrophy but no information on its role in human hypertension and left ventricular hypertrophy (LVH). We hypothesized that ...
    • Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia ... 
      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rose Marie; Díaz Araya, Guillermo; Vukasovic Ramírez, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (SOC MEDICA SANTIAGO, 2008-11)
      Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important ...
    • Interactions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure ... 
      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rosemarie; Díaz Araya, Guillermo; Vukasovic, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (2008)
      Background: ß adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, ß1 and ß2 AR regulate cardiac contractility and frequency and are important pharmacological ...
    • Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial ... 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Chiong Lay, Mario; Muñoz, David; Riveros, Juan Pablo; Ebensperger González, Roberto; Sabat, Sebastián; Irarrázabal, Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-08)
      This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
    • Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting ... 
      Jalil Milad, Jorge; Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Godoy, Iván; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-09-15)
      In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...