Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy
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2014Metadata
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Gabrielli, Luigi A.
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Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy
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Abstract
background
There is experimental evidence on the role of Rho-kinase (ROCK) activation
in cardiac hypertrophy but no information on its role in human
hypertension and left ventricular hypertrophy (LVH). We hypothesized
that ROCK activity is higher in hypertensive patients with LVH compared
with hypertensive patients without LVH.
methods
We conducted a cross-sectional study comparing untreated hypertensive
patients with (n = 41) and without LVH (n = 46) determined by
echocardiography with a healthy normotensive control group (n = 51).
Measurements included LV mass, dimensions, and function and ROCK
activity determined in circulating leukocytes by measuring Western
blot levels of phosphorylated to total myosin light chain phosphatase
1 (MYPT1-p/t).
results
Compared with normotensive subjects, MYPT1-p/t was significantly
increased by 4.5-fold in the hypertensive patients without LVH and by
9-fold in the hypertensive patients with LVH. Compared with the hypertension
without LVH group, MYPT1-p/t was significantly increased by
2-fold in the hypertension with LVH gorup. In patients with eccentric
LVH, the mean MYPT1-p/t ratio was significantly higher by 4-fold compared
with hypertensive patients without eccentric LVH. Patients with
an E/e´ ratio ≥15 (n = 6) showed a higher MYPT1-p/t ratio (by 26%) compared
with patients with a lower E/e´ ratio (P ≤ 0.01).
conclusions
ROCK activity is higher in hypertensive patients with LVH compared
with hypertensive patients without LVH, and it is further increased
when eccentric LVH is present. Thus, in hypertension, ROCK activation
is related to pathological cardiac remodeling and might have a role as
an LVH marker.
General note
Artículo de publicación ISI
Patrocinador
This work was supported by Fondecyt grants 1085208 and
1121060 (Chile) to J.E.J.
Quote Item
American Journal of Hypertension 27(6) June 2014
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