Browsing by Author "Latorre, Ramón"
Now showing items 1-20 of 27
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(2003)It has been shown that innocent ligands always contribute with a similar electron density to a metal centre in a complex regardless of which other innocent ligands are bonded to the same centre, while non-innocent ligands ...
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(BIOPHYSICAL SOCIETY, 2001-05)The mechanism by which the cytoskeletal protein actin affects the conductance of amiloride-sensitive epithelial sodium channels (ENaC) was studied in planar lipid bilayers. In the presence of monomeric actin, we found a ...
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(AMER ASSOC ADVANCEMENT SCIENCE, 1999-09-17)Maxi-K channels consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher Ca2+ sensitivity. Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) ...
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(BIOPHYSICAL SOCIETY, 2003-04)CIC-4 and CIC-5 are mammalian CIC isoforms with unique ion conduction and gating properties. Macroscopic current recordings in heterologous expression systems revealed very small currents at negative potentials, whereas a ...
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(NATL ACAD SCIENCES, 2000-11-21)The voltage- and Ca2+-acttiated K+ (K-V,K-Ca) channel is expressed in a variety of polarized epithelial cells seemingly displaying a tissue-dependent apical-to-basolateral regionalization, as revealed by electrophysiology. ...
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(AMER PHYSIOLOGICAL SOC, 2002-03)We studied the effect of H2O2 on the gating behavior of large-conductance Ca2+-sensitive voltage-dependent K+ (K-V,K-Ca) channels. We recorded potassium currents from single skeletal muscle channels incorporated into ...
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(ROCKEFELLER UNIV PRESS, 2001-02)In Shaker K+ channel, the amino terminus deletion Delta6-46 removes fast inactivation (N-type) unmasking a slow inactivation process. In Shaker Delta6-46 (Sh-IR) background, two additional mutations (T449V-I470C) remove ...
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(Amer Assoc Advancement Science, 2021)Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM1 (transmembrane BAX ...
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Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels (ROCKEFELLER UNIV PRESS, 1997-11)Prolonged depolarization induces a slow inactivation process in some Ki channels. We have studied ionic and gating currents during long depolarizations in the mutant Shaker H4-Delta(6-46) K+ channel and in the nonconducting ...
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(ROCKEFELLER UNIV PRESS, 2000-02)When attached outside the voltage-sensing S4 segment of the Shaker potassium channel, the fluorescent probe tetramethylrhodamine (TMRM) undergoes voltage-dependent fluorescence changes (Delta F) due to differential interaction ...
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Determination of the stoichiometry between alpha- and gamma 1 subunits of the BK channel using LRET (Cell Press, 2018)Two families of accessory proteins, beta and gamma, modulate BK channel gating and pharmacology. Notably, in the absence of internal Ca2+, the gamma 1 subunit promotes a large shift of the BK conductance-voltage curve to ...
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(ROCKEFELLER UNIV PRESS, 2005-04)High conductance, calcium- and voltage-activated potassium (BK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory (beta) ...
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(1969)THE effect of temperature on the resting potential has been studied in a number of different preparations1-3, and has attracted considerable theoretical interest. In the axons of the squid Loligo forbesi, the resting ...
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(2004)A series of dinuclear iron (III) complexes with carboxylate bridges, of the type [Fe2L2(H20)4](NO 3)2(H2O)m (m=1-3), where L=Schiff base derived from L-α-amino acids and salicylaldehyde have been prepared and characterised ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2006-06-19)Mixed valence dinuclear iron(II,III) complexes of the type [Fe2L2(H2O)(4)](NO3)(H2O)(3), where L is the dianion of a Schiff base ligand derived from alpha-amino acids (glycine and L-isolecine) and 5-bromosalicylaldehyde, ...
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(ROCKEFELLER UNIV PRESS, 2008-02)The internal vestibule of large-conductance Ca2+ voltage-activated K+ (BK) channels contains a ring of eight negative charges not present in K+ channels of lower conductance (Glu386 and Glu389 in hSlo) that modulates channel ...
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(Nature, 2015)The Na+/ K+-ATPase restores sodium (Na+) and potassium (K+) electrochemical gradients dissipated by action potentials and ion-coupled transport processes. As ions are transported, they become transiently trapped between ...
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(ROCKEFELLER UNIV PRESS, 2000-02)In Shaker K+ channels depolarization displaces outwardly the positively charged residues of the S4 segment. The amount of this displacement is unknown, but large movements of the S4 segment should be con strained by the ...
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(ROCKEFELLER UNIV PRESS, 2003-10)Animal and plant voltage-gated ion channels share a common architecture. They are made up of four subunits and the positive charges on helical S4 segments of the protein in animal K+ channels are the main voltage-sensing ...
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(NATL ACAD SCIENCES, 2001-08-14)Upon depolarization positive charges contained in the transmembrane segment S4 of voltage-dependent channels are displaced from the cytoplasmic to the external milieu, This charge movement leads to channel opening. In ...
