About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Ciencias
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit

Artículo
Thumbnail
Open/Download
IconValverde MA-Acute.pdf (154.0Kb)
Publication date
1999-09-17
Metadata
Show full item record
Cómo citar
Valverde, Miguel A.
Cómo citar
Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit
.
Copiar
Cerrar

Author
  • Valverde, Miguel A.;
  • Rojas, Patricio;
  • Amigo, Julio;
  • Cosmelli, Diego;
  • Orio, Patricio;
  • Bahamonde Miranda, María Inés;
  • Mann, Giovanni E.;
  • Vergara Montecinos, Cecilia;
  • Latorre, Ramón;
Abstract
Maxi-K channels consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher Ca2+ sensitivity. Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) only when both a and beta subunits were present. This activation was independent of the generation of intracellular signals and could be triggered by estradiol conjugated to a membrane-impenetrable carrier protein. This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/118675
ISSN: 0036-8075
Quote Item
SCIENCE Volume: 285 Issue: 5435 Pages: 1929-1931 Published: SEP 17 1999
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account