| Author | dc.contributor.author | Valverde, Miguel A. | |
| Author | dc.contributor.author | Rojas, Patricio | es_CL |
| Author | dc.contributor.author | Amigo, Julio | es_CL |
| Author | dc.contributor.author | Cosmelli, Diego | es_CL |
| Author | dc.contributor.author | Orio, Patricio | es_CL |
| Author | dc.contributor.author | Bahamonde Miranda, María Inés | es_CL |
| Author | dc.contributor.author | Mann, Giovanni E. | es_CL |
| Author | dc.contributor.author | Vergara Montecinos, Cecilia | es_CL |
| Author | dc.contributor.author | Latorre, Ramón | es_CL |
| Admission date | dc.date.accessioned | 2008-03-26T16:40:45Z | |
| Available date | dc.date.available | 2008-03-26T16:40:45Z | |
| Publication date | dc.date.issued | 1999-09-17 | |
| Cita de ítem | dc.identifier.citation | SCIENCE Volume: 285 Issue: 5435 Pages: 1929-1931 Published: SEP 17 1999 | en |
| Identifier | dc.identifier.issn | 0036-8075 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/118675 | |
| Abstract | dc.description.abstract | Maxi-K channels consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher Ca2+ sensitivity. Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) only when both a and beta subunits were present. This activation was independent of the generation of intracellular signals and could be triggered by estradiol conjugated to a membrane-impenetrable carrier protein. This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | en |
| Keywords | dc.subject | VASCULAR SMOOTH-MUSCLE | en |
| Título | dc.title | Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit | en |
| Document type | dc.type | Artículo de revista | |
