Browsing by Author "Morello Casté, Antonio"

Now showing items 1-11 of 11

    • An immunogenetically defined and immunodominant Trypanosoma cruzi antigen 
      Ramos Ramos,Fernanda C.; Juri,; Hoecker, G.; Lavandero González, Sergio; Pena,; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Aguillón Gutiérrez, Juan Carlos; Ferreira e Ferreira, Efigenia (1991)
      Two strains of mice, A. SW (H-2(s)) and A.CA (H-2(f)), were immunized with live trypomastigotes or epimastigotes of the Tulahuen strain of Trypanosoma cruzi or with their sonicates. By immunowestern blotting, sera from ...
    • Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and ... 
      Faúndez, Mario; López Muñoz, Rodrigo; Torres, Gloria; Morello Casté, Antonio; Ferreira, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Maya Arango, Juan (AMER SOC MICROBIOLOGY, 2008)
      L-Buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden ...
    • Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones 
      Otero, Lucía; Maya Arango, Juan; Morello Casté, Antonio; Rigol, C.; Barriga, Germán; Rodríguez, J.; Folch, C.; Norambuena, Ester; González, M.; Olea Azar, Claudio; Cerecetto, Hugo; Gambino, Dinorah (Bentham Science Publishers Ltd., 2008)
      In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of ...
    • Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
    • Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about ... 
      Seguel, Verónica; Castro, Lorena; Reigada, Chantal; Cortés, Leonel; Díaz, María V.; Miranda, Mariana R.; Pereira, Claudio A.; Lapier, Michel; Campos Estrada, Carolina; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya, Juan D.; Lopez Muñoz, Rodrigo (Elsevier, 2016)
      Benznidazole is the first-line drug used in treating Chagas disease, which is caused by the parasite Trypanosoma cruzi (T. cruzi). However, benznidazole has limited efficacy and several adverse reactions. Pentamidine is ...
    • Protection of vascular endothelium by aspirin in a murine model of chronic Chagas’ dise 
      Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Ferreira, Jorge; Morello Casté, Antonio; López Muñoz, Rodrigo; Maya Arango, Juan (Springer, 2013)
      Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
    • Purification and preliminary sequencing of Tc45, an immunodominant Trypanosoma cruzi antigen: Absence of ... 
      Aguillón Gutiérrez, Juan Carlos; Bustos,; Vallejos, Carla; Hermosilla, Manuel; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Hellman,; Orn,; Ferreira e Ferreira, Efigenia (American Society of Tropical Medicine and Hygiene, 1995)
      In spite of being separated by more than 20 million years of evolution, the murine and human immune systems share extensive similarities. Thus, experimental results obtained with the murine model may have predictive value ...
    • t-Butyl-4-hydroxyanisole, a novel respiratory chain inhibitor. Effects on Trypanosoma cruzi epimastigotes 
      Aldunate, Jorge; Ferreira, Jorge; Letelier Muñoz, María Eugenia; Repetto Scaramelli, Yolanda; Morello Casté, Antonio (1986)
      t-Butyl-4-hydroxyanisole, an antioxidant food additive, inhibited the growth of Trypanosoma cruzi by almost 100% at 0.5 mM concentration. This compound inhibited 70% of oxygen consumption of epimastigotes. The redox level ...
    • Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi 
      Morello Casté, Antonio; Lipchenca, I.; Cassels Niven, Bruce; Speisky Cosoy, Hernán; Aldunate, J.; Repetto Scaramelli, Yolanda (Elsevier Science Ltd., 1993-11-01)
      The alkaloids boldine, glaucine, predicentrine, apomorphine, coclaurine, norarmepavine and codeine were tested against the epimastigotes of the Tulahuén and LQ strains and the DM 28c clone of Trypanosoma cruzi. The ...
    • Trypanosoma cruzi: Carboxylesterase activity in intact epimastigotes 
      Repetto Scaramelli, Yolanda; Aldunate,; Morello Casté, Antonio (1983)
      1. 1. Carboxylesterase activity corresponding to types A and B has been demonstrated in intact T. cruzi epimastigotes as shown by the hydrolysis of several esters of p-nitrophenol and the effect of suitable inhibitors. 2. ...
    • Trypanosoma cruzi: In vitro effect of aspirin with nifurtimox and benznidazole 
      López Muñoz, Rodrigo; Faúndez, Mario; Klein, Sebastián; Escanilla, Sebastián; Torres, Gloria; Lee-Liu, Dasfne; Ferrada Parker, Jorge; Kemmerling Weis, Ulrike; Orellana Bown, Myriam; Morello Casté, Antonio; Ferreira, Arturo; Maya Arango, Juan (ELSEVIER, 2010)
      Nifurtimox and benznidazole are the only active drugs against Trypanosoma cruzi; however, they have limited efficacy and severe side effects. During primoinfection, T. cruzi infected macrophages mount an antiparasitic ...