Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4461-4480 of 5085

    • Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway 
      Altamirano, Francisco; Oyarce, César; Silva, Patricio; Toyos, Marcela; Wilson, Carlos; Lavandero González, Sergio; Uhlen, L.; Estrada, M. (BIOSCIENTIFICA LTD, 2009-08)
      Elevated testosterone concentrations induce cardiac hypertrophy but the molecular mechanisms are poorly understood. Anabolic properties of testosterone involve in increase in protein synthesis. The mammalian target of ...
    • Substituent effect on the rate of the hydroxyl and phenyl radical spin trapping with nitrones 
      Sueishi, Y.; Yoshioka, C.; Olea Azar, Claudio; Reinke, L. A.; Kotake, Y. (CHEMICAL SOC JAPAN, 2002-09)
      Hydroxyl and phenyl radical spin trapping rates by alpha-phenyl-N-t-butylnitrone (PBN, N-benzylidene-t-butylamine N-oxide) and its analogs were determined using a competitive trapping method. Hydroxyl radical was generated ...
    • Use of human mesenchymal cells to improve vascularization in a mouse model for scaffold-based dermal regeneration 
      Egaña, José T.; Fierro, Fernando Antonio; Krueger, Stefan; Bornhaeuser, Martin; Huss, Ralf; Lavandero González, Sergio; Machens, Hans-Guenther (Mary Ann Liebert, 2009)
      All engineered bioartificial structures developed for tissue regeneration require oxygen and nutrients to establish proper physiological functions. Aiming to improve vascularization during dermal regeneration, we combined ...
    • The IKK complex contributes to the induction of autophagy 
      Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Helene; Maiuri, M. C.; Morselli, E.; Vitale, I.; Kepp, O.; Tasdemir, E.; Galluzzi, Lorenzo; Shen, S.; Tailler, M.; Delahaye, N.; Tesniere, A.; De Stefano, D.; Ben Younes, Amena; Harper, F.; Pierron, G.; Lavandero González, Sergio; Zitvogel, L.; Israel, A; Baud, V; Kroemer, Guido (NATURE PUBLISHING GROUP, 2010-02-03)
      In response to stress, cells start transcriptional and transcription-independent programs that can lead to adaptation or death. Here, we show that multiple inducers of autophagy, including nutrient depletion, trigger the ...
    • Photoreduction of 4-substituted nitrobenzenes by amines 
      Norambuena V., Ester; Olea Azar, Claudio; Rufs, A. M.; Encinas, M. V. (ROYAL SOC CHEMISTRY, 2004-03-21)
      The reduction of several nitrobenzenes bearing electron-donor and electron-withdrawing substituents in the 4-position by triethylamine in acetonitrile was studied by cyclic voltammetry, EPR spectroscopy, and steady-state ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v ... 
      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...
    • Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide 
      Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Troncoso Cotal, Rodrigo; Toro, Barbra; Pedrozo Cibils, Zully; Díaz Elizondo, Jessica; Salas, Daniela; Parra Ortíz, María Valentina; Núñez González, Marco; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2010-02-15)
      We investigate here the role of reactive oxygen species and nitric oxide in iron-induced cardiomyocyte hypertrophy or cell death Cultured rat cardiomyocytes incubated with 20 mu M iron (added as FeCl3-Na nitrilotriacetate, ...
    • Theoretical study on electronic spectra and aurophilic attraction in [Au-3(MeN=COMe)(3)](n) (n-1-4) complexes 
      Mendizábal Emaldía, Fernando; Aguilera, Benjamín; Olea Azar, Claudio (ELSEVIER SCIENCE BV, 2007-10-25)
      The aurophilic attraction and the spectroscopic properties of [AU(3)(MeN=COMe)(3)](n) (n = 1-4) were studied at the MP2 and density functional theory (B3LYP and PBE) levels. Theoretical calculations at the MP2 level are ...
    • Theoretical study on the electronic spectrum of [M(CN)(2)](n)(-n) (M = Au(I), Ag(I); n=1-3) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Briones, Rodolfo (ELSEVIER SCIENCE BV, 2006-05-30)
      The electronic structure and the spectroscopic properties of [M(CN)(2)](n)(-n), (M = Au(I), Ag(I); n = 1-3) were studied using density functional theory (DFT) at the B3LYP level. The absorption spectrums in these complexes ...
    • Theoretical study of the interaction d(10)-s(2) between Pt(0) and metals on the [Pt(PH3)(3)M] complexes (M ... 
      Mendizábal Emaldía, Fernando; Donoso, Daniela; Olea Azar, Claudio; Mera, Raúl (ELSEVIER SCIENCE BV, 2007-02-18)
      We studied the attraction between [Pt(PH3)(3)] and the metals (Hg(0) and Au(-I)) in the hypothetical [Pt(PH3)(3)M] isoelectronic complexes using ab initio methodology. We found that the changes around the equilibrium ...
    • Theoretical study of the interaction d(10)-d(8) between Pt(0) and M(I) on the [Pt(PH3)-MPH3](+) complexes ... 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Miranda, Sebastián (JOHN WILEY & SONS INC, 2007-05)
      Ab initio calculations suggest that a series of complexes of type [Pt(PH3)(3)-MPH3](+) (M = Au, Ag, Cu) are stable. We found that changes around the equilibrium distance Pt-M and in the interaction energies are sensitive ...
    • Theoretical study of the electronic spectrum of binuclear gold(I) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2005-05-15)
      The electronic structure and the spectroscopic properties of [Au-2(CS3)(2)](-2), [Au-2(pym-2-S)(2)] (pym = pyrimidethiolate), [Au-2(dpm)(2)](+2) (dpm = bis(diphosphino)methane) were studied using density functional theory ...
    • Theoretical Study of Electronic Spectra of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n=3-5) Complexes 
      Mendizábal Emaldía, Fernando; Burgos, Darwin; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2009-03-05)
      The platinum-platinum attraction and the spectroscopic properties of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n = 3-5) were Studied at the PBE level. Theoretical calculations are in agreement with experimental geometries. The ...
    • Theoretical study on 5-nitrofuryl thiosemicarbazone radicals electronic properties 
      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; González, M. (ELSEVIER SCIENCE BV, 2006-09-29)
      Theoretical studies of molecular conformations and electronic properties calculations of eight 5-nitrofuryl thiosemicarbazone free radicals, by means of ab initio (R/UHF), and DFT (R/UB3LYP) methods are presented and ...
    • Theoretical study in [C2H4-Tl](+) and [C2H2-Tl](+) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2007-01)
      We studied the attraction between [C2Hn] and Tl(I) in the hypothetical [C2Hn-Tl](+) complexes (n = 2,4) using ab initio methodology. We found that the changes around the equilibrium distance C-Tl and in the interaction ...
    • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion 
      Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species 
      Rojas Rivera, Andrés; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Salas, Daniela; Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Chiong Lay, Mario; Olea Azar, Claudio; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2009-11-03)
      We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic ...
    • Phthalocyanoiron complex with bridged ligands. Electronic structure of monomers and polymers 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Briones, Rodolfo (JOHN WILEY & SONS INC, 2001-04-15)
      Electronic structure aspects related to the semiconducting properties of monomers and polymers of phythalocyanoiron with bidentate bridging ligands, PcFe-L-2 and -[PcFe(L)](n), have been investigated from density functional ...
    • Poly(N-phenylmaleimide-co-acrylic acid)-copper(II) and poly(N-phenylmaleimide-co-acrylic acid)-cobalt(II) ... 
      Marambio, Oscar G.; Pizarro, Guadalupe del Carmen; Jeria Orell, Manuel; Huerta, Margarita R.; Olea Azar, Claudio; Habicher, W. D. (0887-624X, 2005-10-15)
      The free-radical copolymerization of N-phenylmaleimide (N-PhMI) with acrylic acid was studied in the range of 25-75 mol % in the feed. The interactions of these copolymers with Cu(H) and Co(H) ions were investigated as a ...