Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4481-4500 of 5085

    • New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological ... 
      Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)
      New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
    • In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl ... 
      Aguirre, G.; Boiani, Lucía; Cerecetto, Hugo; Fernández, M.; González, M.; Denicola, Ana; Otero, L.; Gambino, Dinorah; Rigol Olsen, Carolina; Olea Azar, Claudio; Faúndez Cáceres, Mario Antonio (PERGAMON-ELSEVIER SCIENCE LTD, 2004-09-15)
      The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine ...
    • ESR and spin trapping studies of two new potential antitrypanosomal drugs 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)
      The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
    • ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Morello Casté, Antonio; Maya Arango, Juan; Moncada, C.; Cabrera, E.; Di Maio, R.; González, M.; Cerecetto, Hugo (TAYLOR & FRANCIS LTD, 2003-08)
      Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
    • Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their ... 
      Speisky Cosoy, Hernán; Gómez, Maritza; Burgos Bravo, Francesca; López Alarcón, Camilo; Jullian Matthaei, Carolina; Olea Azar, Claudio; Aliaga, Margarita E. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03-01)
      The interaction between Cu2+ ions and GSH molecules leads to the swift formation of the physiologically occurring Cu(I)-[GSH](2) complex. Recently, we reported that this complex is able to reduce molecular oxygen into ...
    • Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; Di Maio, R.; Risso, Mariela; González, M.; Porcal, Williams (PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
    • Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs 
      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Otero, Lucía; Gambino, Dinorah; González, M.; Cerecetto, Hugo (PERGAMON-ELSEVIER SCIENCE LTD, 2005-10)
      Cyclic voltammetry and electron spin resonance (ESR) techniques were used in the investigation of several potential antiprotozoal thiosemicarbazones nitrofurane derivatives. A self-protonation process involving the ...
    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones 
      Pagano, Mariana; Demoro, Bruno; Toloza, Jeannette; Boiani, Lucía; González, Mercedes; Cerecetto, Hugo; Olea Azar, Claudio; Norambuena, Ester; Gambino, Dinorah; Otero, Lucía (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], ...
    • Dopamine-dependent iron toxicity in cells derived from rat hypothalamus 
      Paris Pizarro, Irmgard; Martínez Alvarado, P.; Cárdenas, S.; Pérez Pastene, C.; Graumann, Rebecca; Fuentes, P.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Segura Aguilar, Juan (AMER CHEMICAL SOC, 2005-03)
      We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
    • On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: ... 
      Arriagada, C.; Paris Pizarro, Irmgard; Matas, M. J. S. de las; Martínez Alvarado, P.; Cárdenas, S.; Castañeda, P.; Graumann, Rebecca; Pérez Pastene, C.; Olea Azar, Claudio; Couve, E.; Herrero, M. T.; Caviedes Fernández, Pablo; Segura Aguilar, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07)
      Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 muM aminochrome with 100 muM dicoumarol, an ...
    • Metallomacrocycle (MacM) complex with cyanide as bridged ligand: Electronic structures of [MacMCN](n) 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2002-03-15)
      The electronic structures of complexes and one-dimensional metallomacrocycles with cyanide as bridged ligand, such as [MacM(CN)(2)](-) and [MacM(CN)](n) [Mac = phthalocyanine, tetrabenzoporphyrine; M = Co(III), Rh(III)] ...
    • Metal ion retention from aqueous solution using the ultrafiltration technique: preparation, retention ... 
      Pizarro, Guadalupe del Carmen; Marambio, Oscar G.; Jeria Orell, Manuel; Huerta, Margarita R.; Rodríguez, Oscar O.; Olea Azar, Claudio; Rivas, Bernabé L.; Habicher, W. D. (JOHN WILEY & SONS LTD, 2007-01)
      Chlorophenylmaleimide (Cl-PhMI) and N-maleoylglycine (N-MG) with beta-methylhydrogen itaconate (beta-MHI) were copolymerized by radical polymerization, and their metal ion retention capacity (MRC) and thermal behavior were ...
    • Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR ... 
      Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)
      Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
    • Comparative evaluation of the acceptor properties of quinone derivatized polypyridinic ligands 
      Norambuena V., Ester; Olea Azar, Claudio; Delgadillo, Alvaro; Barrera, Mauricio; Loeb, Bárbara (ELSEVIER SCIENCE BV, 2009-05-18)
      The reduction properties of four acceptor polipyridyl ligands modified with quinones were studied by different experimental methods, as cyclic voltammetry and ESR spectroscopy, and by theoretical calculations. ESR spectra ...
    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 
      Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Computer assisted design of potentially active anti-trypanosomal compounds 
      Paulino, M.; Iribarne, F.; Hansz, M.; Vega, M.; Seoane, G.; Cerecetto, Hugo; Di Maio, R.; Caracelli, I.; Zukerman-Schpector, J.; Olea Azar, Claudio; Stoppani, A. O. M.; Berriman, M.; Fairlamb, A. H.; Tapia, O. (ELSEVIER SCIENCE BV, 2002-04-26)
      A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives. ...
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome ... 
      Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, ... 
      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Applications of electron spin, resonance and spin trapping in tropical parasitic diseases 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III 
      Cerecetto, Hugo; González, M.; Risso, Mariela; Saenz, P.; Olea Azar, Claudio; Bruno, A. M.; Azqueta, Amaia; De Cerain, A. L.; Monge, A. (WILEY-V C H VERLAG GMBH, 2004-05)
      New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...