Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4541-4560 of 5085

    • Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat ... 
      Ocaranza, María Paz; Piddo Mijares, Ana María; Faúndez Fuentes, Perla Andrea; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2002-03)
      Background and objective In humans, the insertion/ deletion polymorphism in the anglotensin (Ang) I converting enzyme (ACE) gene significantly determines ACE activity. The deletion allele induces higher ACE levels and is ...
    • Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and ... 
      Michea Acevedo, Luis; Delpiano Barriga, Ana María; Hitschfeld, C.; Lobos González, Lorena; Lavandero González, Sergio; Marusic, Elisa (ENDOCRINE SOC, 2005-03)
      There is increasing evidence for rapid nongenomic effects of aldosterone. Aldosterone has been demonstrated to alter intracellular pH and calcium in isolated cells. However, few studies have correlated these effects with ...
    • Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Carreño, J. E.; Muñoz, David; Riveros, Juan Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (AMER PHYSIOLOGICAL SOC, 2004-02-01)
      In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
    • IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent 
      Díaz Araya, Guillermo; Borg, T. K.; Lavandero González, Sergio; Loftis, M. J.; Carver, W. (TAYLOR & FRANCIS LTD, 2003-05)
      The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...
    • Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of ... 
      Gálvez, A. S.; Ulloa Valenzuela, Juan Alberto; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Eisner, Verónica; Barros, L.; Lavandero González, Sergio (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
      Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
    • Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting ... 
      Jalil Milad, Jorge; Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Godoy, Iván; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-09-15)
      In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...
    • Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients ... 
      Castro, Pablo; Greig, Douglas; Pérez, Osvaldo; Moraga, Francisco; Chiong Lay, Mario; Díaz Araya, Guillermo; Padilla, Ivonne; Nazzal Nazal, Carolina; Jalil Milad, Jorge; Vukasovic Ramírez, José Luis; Moreno, M.; Corbalán, Ramón; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-07-15)
    • Comparative cytotoxicity of alkyl gallates on mouse tumor cell lines and isolated rat hepatocytes 
      Frey, Christian; Pavani, Mario; Cordano, Gianni; Muñoz, Sergio; Rivera, Enrique; Medina, Jorge; Morello Casté, Antonio; Maya Arango, Juan; Ferrada Parker, Jorge (ELSEVIER, 2007)
      Alkyl esters of gallic acid inhibited the respiration rate of mouse sarcoma 786A and mouse mammary adenocarcinoma TA3 cell lines and its multiresistant variant TA3-MTX-R more effectively than gallic acid, both in the ...
    • Perinatal Asphyxia Induces Neurogenesis in Hippocampus: an Organotypic Culture Study 
      Morales, P.; Huaiquín, P.; Bustamante, D.; Fiedler Temer, Jenny; Herrera-Marschitz Muller, Mario (F.P. Graham Publishing Co., 2007)
      There is clinical and experimental evidence indicating that neurocircuitries of the hippocampus are vulnerable to hypoxia/ischemia occurring at birth, inducing, upon re-oxygenation/re-circulation, delayed neuronal ...
    • Pleiotropic effects of atorvastatin in heart failure: Role in oxidative stress, inflammation, endothelial ... 
      Castro, P.; Miranda, Rodrigo; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Alcaíno Olivares, Hernán Alejandro; Chiong Lay, Mario; Bustos Contreras, Carlos Andrés; García Nannig, Lorena; Mellado, Rose Marie; Vukasovic Ramírez, José Luis; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2008-04)
      Background: Increased oxidative stress, a common feature in chronic heart failure, has been associated with inflammation, endothelial dysfunction, and extracellular matrix degradation. Statins have known anti-inflammatory ...
    • Perindopril regulates beta-agonist-induced cardiac apoptosis 
      Gálvez, A. S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2005-09)
      Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes 
      Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth ... 
      Foncea Avila, Rocío; Gálvez, Anita; Pérez Montes, Viviana; Morales, María Paz; Calixto, Andrea; Meléndez Vergara, Jaime; González Jara, Fabián Rodrigo; Díaz Araya, Guillermo; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-07-05)
      This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Hager Ribeiro, Carolina; López Bartolucci, Carolina; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm; Ferreira, Arturo (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03)
      Trypanosoma cruzi (T cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There is ...
    • Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaíno Olivares, Hernán Alejandro; Bustos Contreras, Carlos Andrés; Vukasovic Ramírez, José Luis; Godoy, Iván; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2007-03-06)
      Meeting Abstract
    • Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart ... 
      Pérez, Osvaldo; Castro Agüero, Pablo; Díaz Araya, Guillermo; Nettle Nettle, Daniels Maurice; Moraga, Francisco; Chiong Lay, Mario; Jalil Milad, Jorge; Zalaquett Sepúlveda, Ricardo; Morán, Sergio; Becker, Pedro; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2002-08)
      Introduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac ...
    • Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by ... 
      Stehr, Carlos B.; Carvajal, Cristián A.; Lacourt, Patricia; Alcaíno Olivares, Hernán Alejandro; Mellado, Rose Marie; Cattani, Andreína; Mosso, Lorena; Lavandero González, Sergio; Fardella, Carlos E. (SOC MEDICA SANTIAGO, 2008-09)
      Background: Type I familial hyperaldosteronism is caused by the presence of a chimaeric gene CYP11B1/CYP11B2 which encodes an enzyme with aldosterone synthetase activity regulated by adernocorticotrophic hormone (ACTH). ...
    • Activity of metalloproteinase-9 is related to oxidative stress in the acute coronary syndrome 
      Bittner, Alex; Castro Agüero, Pablo; Pérez, Osvaldo; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (OXFORD UNIV PRESS, 2006-08)
      Meeting Abstract