Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4561-4580 of 5198

    • Synthesis of a Novel Series of 4-Arylpiperazinyl Derivatives Linked to a 2-(Pyridin-3-yl)-1H-benzimidazole ... 
      Pessoa Mahana, David; Núñez, Andrés; Espinosa Bustos, Christian; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán (2010)
      The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d]imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl)alkyl)-2-(pyridin-3-yl)-1H-b ...
    • Effect of hydrostatic high-pressure treatment on proteins, lipids and nucleotides in chilled farmed salmon ... 
      Ortea, Ignacio; Rodríguez Melis, Alicia; Tabilo Munizaga, Gipsy; Pérez Won, Mario; Aubourg, Santiago P. (Springer, 2010)
      The effect of a previous hydrostatic highpressure (HHP) treatment on hydrolysis, breakdown and aggregation events in chemical constituents of chilled farmed coho salmon (Oncorhynchus kisutch) was studied. Three different ...
    • Contraction-related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells 
      Niu, Wenyan; Bilan, Philip J.; Ishikura, Shuhei; Schertzer, Jonathan D.; Contreras Ferrat, Ariel Eduardo; Fu, Zhengxiang; Liu, Jie; Boguslavsky, Shlomit; Foley, Kevin P.; Liu, Zhi; Li, Jinru; Chu, Guilan; Panakkezhum, Thomas; Lopaschuk, Gary D.; Lavandero González, Sergio; Yao, Zhi; Klip, Amira (2010)
      Contraction-related stimuli regulate GLUT4 traffic in C2C12- GLUT4myc skeletal muscle cells. Am J Physiol Endocrinol Metab 298: E1058 –E1071, 2010. First published February 16, 2010; doi:10.1152/ajpendo.00773.2009.—Muscle ...
    • A system for detection of volatile antioxidant commonly emitted from spices and medicinal herbs. Un sistema ... 
      Pastene, Edgar; Gómez, Maritza; Speisky Cosoy, Hernán; Núñez Vergara, Luis (SOC BRASILEIRA QUIMICA, 2009)
      An apparatus which allows the direct measurement of the antioxidant capacity of volatiles compounds emitted from some herbs and culinary spices is described. The device comprises: a sample chamber, a mixing chamber, a pump ...
    • A protocol for evaluating the safety of herbal preparations in a rat model: the case of a supercritical ... 
      Letelier Muñoz, María Eugenia; Aracena Parks, Paula; Peredo Silva, Liliana (2010)
      Herbal extracts must be evaluated for their efficacy and safety. In vivo acute toxicity studies must consider the different mechanisms by which active compounds may elicit toxicological outcomes. Thus, a methodology to ...
    • Polychlorinated biphenyl behavior in soils amended with biosolids 
      Leiva, Claudio; Ahumada, Inés; Sepúlveda, Betsabet; Richter Duk, Pablo (ELSEVIER, 2010)
      Assessment of the mobility of polychlorinated biphenyls (PCBs) in soils, amended with biosolids at a rate of 30 Mg ha 1, was performed using an incubation process and leaching columns. The incubation process was carried ...
    • Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice 
      Lasagna Reeves, C.; González Romero, D.; Barría, M. A.; Olmedo, I.; Clos, A.; Sadagopa Ramanujam, V. M.; Urayama, A.; Vergara, L.; Kogan Bocian, Marcelo; Soto, C. (ELSEVIER, 2010)
      Gold nanoparticles (GNPs) offer a great promise in biomedicine. Currently, there is no data available regarding the accumulation of nanoparticles in vivo after repeated administration. The purpose of the present study ...
    • ESR and electrochemical study of 1,2-disubstituted 5-nitroindazolin-3-ones and 2-substituted 3-alkoxy-5-n ... 
      Folch, Christian; Olea Azar, Claudio; Arán, Vicente J.; Díaz Urrutia, Christian (ELSEVIER, 2010)
      Two families of 5-nitroindazole derivatives were electrochemically studied in an aprotic solvent using cyclic voltammetry (CV) technique. The produced nitro-anion radical species were characterized using electron spin ...
    • The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 
      Vicencio, José Miguel; Ortíz, C.; Criollo Céspedes, Alfredo; Jones, A. W. E.; Kepp, O.; Galluzzi, Lorenzo; Joza, N.; Vitale, I.; Morselli, E.; Tailler, M.; Castedo, M.; Maiuri, M. C.; Molgó, Jordi; Szabadkai, G.; Lavandero González, Sergio; Kroemer, Guido (NATURE PUBLISHING GROUP, 2009-07)
      The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
    • Effect of high-pressure treatment on microbial activity and lipid oxidation in chilled coho salmon 
      Aubourg, Santiago P.; Tabilo Munizaga, Gipsy; Reyes, Juan E.; Rodríguez, Alicia; Pérez Won, Mario (Wiley InterScience, 2010)
      This work studies the effect of a previous hydrostatic high-pressure (HHP) treatment on chilled farmed coho salmon (Oncorhynchus kisutch). Three different HHP conditions were applied (135 MPa-30 s, 170 MPa-30 s, and 200 ...
    • Prevalence of the angiotensin I converting enzyme insertion deletion polymorphism, plasma angiotensin ... 
      Jalil Milad, Jorge; Piddo Mijares, Ana María; Córdova, Samuel; Chamorro, Gastón; Braun J., Sandra; Jalil, R.; Vega, J.; Jadue, P. L.; Lavandero González, Sergio; Lastra, P. (ELSEVIER SCIENCE INC, 1999-07)
      The aim of this study was to estimate the prevalence of the different alleles of the angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and associated plasma ACE activity, as well as cardiac ...
    • Uric acid, xanthine oxidase and heart failure: Unresolved issues 
      Verdejo, Hugo; Greig, Douglas; Castro, Pablo; Alcaíno Olivares, Hernán Alejandro; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Pizarro, Marcela (OXFORD UNIV PRESS, 2008-12)
    • Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 ... 
      Altamirano, Francisco; Oyarce, César; Silva, Patricia; Toyos, Marcela; Wilson, Carlos; Lavandero González, Sergio; Uhlen, P.; Estrada, M. (BIOSCIENTIFICA LTD, 2009-09)
      Correction.
    • Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway 
      Altamirano, Francisco; Oyarce, César; Silva, Patricio; Toyos, Marcela; Wilson, Carlos; Lavandero González, Sergio; Uhlen, L.; Estrada, M. (BIOSCIENTIFICA LTD, 2009-08)
      Elevated testosterone concentrations induce cardiac hypertrophy but the molecular mechanisms are poorly understood. Anabolic properties of testosterone involve in increase in protein synthesis. The mammalian target of ...
    • Substituent effect on the rate of the hydroxyl and phenyl radical spin trapping with nitrones 
      Sueishi, Y.; Yoshioka, C.; Olea Azar, Claudio; Reinke, L. A.; Kotake, Y. (CHEMICAL SOC JAPAN, 2002-09)
      Hydroxyl and phenyl radical spin trapping rates by alpha-phenyl-N-t-butylnitrone (PBN, N-benzylidene-t-butylamine N-oxide) and its analogs were determined using a competitive trapping method. Hydroxyl radical was generated ...
    • Use of human mesenchymal cells to improve vascularization in a mouse model for scaffold-based dermal regeneration 
      Egaña, José T.; Fierro, Fernando Antonio; Krueger, Stefan; Bornhaeuser, Martin; Huss, Ralf; Lavandero González, Sergio; Machens, Hans-Guenther (Mary Ann Liebert, 2009)
      All engineered bioartificial structures developed for tissue regeneration require oxygen and nutrients to establish proper physiological functions. Aiming to improve vascularization during dermal regeneration, we combined ...
    • The IKK complex contributes to the induction of autophagy 
      Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Helene; Maiuri, M. C.; Morselli, E.; Vitale, I.; Kepp, O.; Tasdemir, E.; Galluzzi, Lorenzo; Shen, S.; Tailler, M.; Delahaye, N.; Tesniere, A.; De Stefano, D.; Ben Younes, Amena; Harper, F.; Pierron, G.; Lavandero González, Sergio; Zitvogel, L.; Israel, A; Baud, V; Kroemer, Guido (NATURE PUBLISHING GROUP, 2010-02-03)
      In response to stress, cells start transcriptional and transcription-independent programs that can lead to adaptation or death. Here, we show that multiple inducers of autophagy, including nutrient depletion, trigger the ...
    • Photoreduction of 4-substituted nitrobenzenes by amines 
      Norambuena V., Ester; Olea Azar, Claudio; Rufs, A. M.; Encinas, M. V. (ROYAL SOC CHEMISTRY, 2004-03-21)
      The reduction of several nitrobenzenes bearing electron-donor and electron-withdrawing substituents in the 4-position by triethylamine in acetonitrile was studied by cyclic voltammetry, EPR spectroscopy, and steady-state ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v ... 
      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...