Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4581-4600 of 5193

    • Theoretical study of the electronic spectrum of binuclear gold(I) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2005-05-15)
      The electronic structure and the spectroscopic properties of [Au-2(CS3)(2)](-2), [Au-2(pym-2-S)(2)] (pym = pyrimidethiolate), [Au-2(dpm)(2)](+2) (dpm = bis(diphosphino)methane) were studied using density functional theory ...
    • Theoretical Study of Electronic Spectra of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n=3-5) Complexes 
      Mendizábal Emaldía, Fernando; Burgos, Darwin; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2009-03-05)
      The platinum-platinum attraction and the spectroscopic properties of [Pt-3(mu-CO)(3)(CO)(3)](n)(-2) (n = 3-5) were Studied at the PBE level. Theoretical calculations are in agreement with experimental geometries. The ...
    • Theoretical study on 5-nitrofuryl thiosemicarbazone radicals electronic properties 
      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; González, M. (ELSEVIER SCIENCE BV, 2006-09-29)
      Theoretical studies of molecular conformations and electronic properties calculations of eight 5-nitrofuryl thiosemicarbazone free radicals, by means of ab initio (R/UHF), and DFT (R/UB3LYP) methods are presented and ...
    • Theoretical study in [C2H4-Tl](+) and [C2H2-Tl](+) complexes 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2007-01)
      We studied the attraction between [C2Hn] and Tl(I) in the hypothetical [C2Hn-Tl](+) complexes (n = 2,4) using ab initio methodology. We found that the changes around the equilibrium distance C-Tl and in the interaction ...
    • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion 
      Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Regulatory volume decrease in cardiomyocytes is modulated by calcium influx and reactive oxygen species 
      Rojas Rivera, Andrés; Díaz Elizondo, Jessica; Parra Ortíz, María Valentina; Salas, Daniela; Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Chiong Lay, Mario; Olea Azar, Claudio; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2009-11-03)
      We investigated the role of Ca2+ in generating reactive oxygen species (ROS) induced by hyposmotic stress (Hypo) and its relationship to regulatory volume decrease (RVD) in cardiomyocytes. Hypo-induced increases in cytoplasmic ...
    • Phthalocyanoiron complex with bridged ligands. Electronic structure of monomers and polymers 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Briones, Rodolfo (JOHN WILEY & SONS INC, 2001-04-15)
      Electronic structure aspects related to the semiconducting properties of monomers and polymers of phythalocyanoiron with bidentate bridging ligands, PcFe-L-2 and -[PcFe(L)](n), have been investigated from density functional ...
    • Poly(N-phenylmaleimide-co-acrylic acid)-copper(II) and poly(N-phenylmaleimide-co-acrylic acid)-cobalt(II) ... 
      Marambio, Oscar G.; Pizarro, Guadalupe del Carmen; Jeria Orell, Manuel; Huerta, Margarita R.; Olea Azar, Claudio; Habicher, W. D. (0887-624X, 2005-10-15)
      The free-radical copolymerization of N-phenylmaleimide (N-PhMI) with acrylic acid was studied in the range of 25-75 mol % in the feed. The interactions of these copolymers with Cu(H) and Co(H) ions were investigated as a ...
    • New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological ... 
      Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)
      New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
    • In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl ... 
      Aguirre, G.; Boiani, Lucía; Cerecetto, Hugo; Fernández, M.; González, M.; Denicola, Ana; Otero, L.; Gambino, Dinorah; Rigol Olsen, Carolina; Olea Azar, Claudio; Faúndez Cáceres, Mario Antonio (PERGAMON-ELSEVIER SCIENCE LTD, 2004-09-15)
      The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine ...
    • ESR and spin trapping studies of two new potential antitrypanosomal drugs 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)
      The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
    • ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Morello Casté, Antonio; Maya Arango, Juan; Moncada, C.; Cabrera, E.; Di Maio, R.; González, M.; Cerecetto, Hugo (TAYLOR & FRANCIS LTD, 2003-08)
      Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
    • Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their ... 
      Speisky Cosoy, Hernán; Gómez, Maritza; Burgos Bravo, Francesca; López Alarcón, Camilo; Jullian Matthaei, Carolina; Olea Azar, Claudio; Aliaga, Margarita E. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03-01)
      The interaction between Cu2+ ions and GSH molecules leads to the swift formation of the physiologically occurring Cu(I)-[GSH](2) complex. Recently, we reported that this complex is able to reduce molecular oxygen into ...
    • Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; Di Maio, R.; Risso, Mariela; González, M.; Porcal, Williams (PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
    • Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs 
      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Otero, Lucía; Gambino, Dinorah; González, M.; Cerecetto, Hugo (PERGAMON-ELSEVIER SCIENCE LTD, 2005-10)
      Cyclic voltammetry and electron spin resonance (ESR) techniques were used in the investigation of several potential antiprotozoal thiosemicarbazones nitrofurane derivatives. A self-protonation process involving the ...
    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones 
      Pagano, Mariana; Demoro, Bruno; Toloza, Jeannette; Boiani, Lucía; González, Mercedes; Cerecetto, Hugo; Olea Azar, Claudio; Norambuena, Ester; Gambino, Dinorah; Otero, Lucía (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], ...
    • Dopamine-dependent iron toxicity in cells derived from rat hypothalamus 
      Paris Pizarro, Irmgard; Martínez Alvarado, P.; Cárdenas, S.; Pérez Pastene, C.; Graumann, Rebecca; Fuentes, P.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Segura Aguilar, Juan (AMER CHEMICAL SOC, 2005-03)
      We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
    • On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: ... 
      Arriagada, C.; Paris Pizarro, Irmgard; Matas, M. J. S. de las; Martínez Alvarado, P.; Cárdenas, S.; Castañeda, P.; Graumann, Rebecca; Pérez Pastene, C.; Olea Azar, Claudio; Couve, E.; Herrero, M. T.; Caviedes Fernández, Pablo; Segura Aguilar, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07)
      Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 muM aminochrome with 100 muM dicoumarol, an ...
    • Metallomacrocycle (MacM) complex with cyanide as bridged ligand: Electronic structures of [MacMCN](n) 
      Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2002-03-15)
      The electronic structures of complexes and one-dimensional metallomacrocycles with cyanide as bridged ligand, such as [MacM(CN)(2)](-) and [MacM(CN)](n) [Mac = phthalocyanine, tetrabenzoporphyrine; M = Co(III), Rh(III)] ...
    • Metal ion retention from aqueous solution using the ultrafiltration technique: preparation, retention ... 
      Pizarro, Guadalupe del Carmen; Marambio, Oscar G.; Jeria Orell, Manuel; Huerta, Margarita R.; Rodríguez, Oscar O.; Olea Azar, Claudio; Rivas, Bernabé L.; Habicher, W. D. (JOHN WILEY & SONS LTD, 2007-01)
      Chlorophenylmaleimide (Cl-PhMI) and N-maleoylglycine (N-MG) with beta-methylhydrogen itaconate (beta-MHI) were copolymerized by radical polymerization, and their metal ion retention capacity (MRC) and thermal behavior were ...