Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4601-4620 of 5097

    • Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative ... 
      Jullian Matthaei, Carolina; Morales Montecinos, Javier; Zapata Torres, Gerald Amilcar; Aguilera, Benjamín; Rodríguez Borges, Jorge; Arán, Vicente J.; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-05-01)
      The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (beta CD) or Heptakis (2,6-di-O-methyl)-beta- cyclodextrin (DM beta CD) were investigated. The stoichiometric ...
    • Consumo de antidepresivos en Chile entre 1992 y 2004 
      Jirón Aliste, Marcela; Machado, Marcio; Ruiz, Inés (SOC MEDICA SANTIAGO, 2008-09)
      Background: Data from the Ministry of Health show that in Chile in 2004, 17% of the population had some form of depression and mood disorders are the tenth cause of disability-adjusted life years (DALY) loss. Aim: To ...
    • Investigation on extraction rate of lanthanides with extractant-impregnated microcapsule 
      Kamio, Eiji; Fujiwara, Yasuhide; Matsumoto, Michiaki; Valenzuela, Fernando; Kondo, Kazuo (ELSEVIER, 2008-05-15)
      Extraction of lanthanum, samarium and erbium into a microcapsule containing 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (EHPNA) is studied. The extraction kinetic model used to predict uptake curves is based on the ...
    • Quantum-chemical, NMR and X-ray diffraction studies on (±)-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane 
      Zapata Torres, Gerald Amilcar; Cassels Niven, Bruce; Parra Mouchet, Julia; Mascarenhas, Yvonne P.; Ellena, Javier; De Araujo, A. S. (Elsevier Inc, 2008-06)
      Time-averaged conformations of ( )-1-[3,4-(methylenedioxy)phenyl]-2-methylaminopropane hydrochloride (MDMA, ‘‘ecstasy’’) in D2O, and of its free base and trifluoroacetate in CDCl3, were deduced from their 1H NMR spectra ...
    • Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello Casté, Antonio; Maya Arango, Juan; Garat, Beatriz; Gambino, Dinorah (ELSEVIER SCIENCE INC, 2008-05)
      In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
    • Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an ... 
      Vieites, Marisol; Smircich, Pablo; Parajón Costa, Beatriz; Rodríguez Borges, Jorge; Galaz, Verónica; Olea Azar, Claudio; Otero, Lucía; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Gómez Barrio, Alicia; Garat, Beatriz; Gambino, Dinorah (SPRINGER, 2008-06)
      In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2- thiol N-oxide were exhaustively characterized and evaluated in ...
    • Senescence, Apoptosis or Autophagy? 
      Vicencio, José Miguel; Galluzzi, Lorenzo; Tajeddine, Nicolás; Ortiz, Carla; Criollo Céspedes, Alfredo; Tasdemir, E.; Morselli, Eugenia; Ben Younes, Amena; Chiara Maiuri, María; Lavandero González, Sergio; Kroemer, Guido (S. Karger AG, 2008)
      Many features of aging result from the incapacity of cells to adapt to stress conditions. When damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two mechanisms to avoid replication. ...
    • Catecholamine uptake, storage, and regulated release by ovarian granulosa cells 
      Greiner, Monika; Paredes Vargas, Alfonso; Rey Ares, Verónica; Saller, Sabine; Mayerhofer, Artur; Lara Peñaloza, Hernán (ENDOCRINE SOC, 2008-10)
      Catecholamines present in the mammalian ovary are involved in many normal aspects of ovarian functions, including initial follicle growth, steroidogenesis, and pathological states such as polycystic ovary syndrome. Sympathetic ...
    • Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 
      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi A.; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; Vivar Sánchez, Raúl; Vukasovic Ramírez, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (SOC MEDICA SANTIAGO, 2008-06)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Synthesis, Characterization, and In Vitro Cytotoxic Activities of Benzaldehyde Thiosemicarbazone Derivatives ... 
      Hernández, Wilfredo; Paz, Juan; Vaisberg, Abraham; Spodine Spiridonova, Evgenia; Richter, Rainer; Beyer, Lothar (HINDAWI PUBLISHING CORPORATION, 2008)
      The palladium (II) bis-chelate Pd (L1-3)(2) and platinum (II) tetranuclear Pt-4(L-4)(4) complexes of benzaldehyde thiosemicarbazone derivatives have been synthesized, and characterized by elemental analysis and IR, FAB(+)-mass ...
    • Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced ... 
      Galarce, Gloria D.; Foncea, Rocío; Edwards, Ana María; Pessoa Mahana, Hernán; Pessoa Mahana, Carlos David; Ebensperger González, Roberto (SOC BIOLGIA CHILE, 2008)
      This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
    • Marcadores de inflamación endotelial subclínica en una familia con hiperaldosteronismo familiar tipo I por ... 
      Stehr, Carlos B.; Carvajal, Cristián A.; Lacourt, Patricia; Alcaíno Gálvez, Hernán Alejandro; Mellado, Rose Marie; Cattani, Andreína; Mosso, Lorena; Lavandero González, Sergio; Fardella, Carlos E. (SOC MEDICA SANTIAGO, 2008-09)
      Type I familial hyperaldosteronism is caused by the presence of a chimaeric gene CYP11B1/CYP11B2 which encodes an enzyme with aldosterone synthetase activity regulated by adrenocorticotrophic hormone (ACTH). Therefore, ...
    • Neonatal Exposure to Estradiol Valerate Programs Ovarian Sympathetic Innervation and Follicular Development ... 
      Sotomayor Zárate, Ramón; Dorfman, Mauricio; Paredes Vargas, Alfonso; Lara Peñaloza, Hernán (SOC STUDY REPRODUCTION, 2008-04)
      A single injection of estradiol valerate (EV) to 14-day-old rats (when the ovarian follicle population has been already established) disrupts cyclicity, increases the activity of key enzymes of androgen biosynthesis, ...
    • Determination of iron in water samples by adsorptive stripping voltammetry with a bismuth film electrode ... 
      Segura, Rodrigo; Toral Ponce, María; Arancibia, Verónica (ELSEVIER SCIENCE BV, 2008-05-30)
      An adsorptive stripping voltammetry method for the determination of iron has been developed. The procedure is based on the adsorptive collection of a complex of iron with 1-(2-piridylazo)-2-naphthol (PAN) on a bismuth-coated ...
    • Evaluating average bioequivalence using methods for high variability drugs: A case study 
      Sánchez, M. P.; Gómez, C.; Carrasco, J. L.; Ocaña, J.; von Plessing, C.; Godoy, C. G.; Reinbach, R.; Godoy, R. (DUSTRI-VERLAG DR KARL FEISTLE, 2008-10)
      The purpose of this study was to determine if different methods for average bioequivalence in high variability drugs coincide or not in their conclusions when applied to the same dataset, and to discuss the method validity ...
    • Synthesis and characterization of new complexes of the type [Ru(CO)(2)Cl-2 (2-phenyl-1,8-naphthyridine-kN) ... 
      Moya, Sergio A.; Gajardo, Juana; Araya, Juan Carlos; Cornejo, Jaime J.; Guerchais, Veronique; Le Bozec, Hubert; Bayón, J. Carles; Pardey, Alvaro J.; Aguirre Álvarez, Pedro (JOHN WILEY & SONS, 2008-08)
      Novel ruthenium (II) complexes were prepared containing 2-phenyl-1,8-naphthyridine derivatives. The coordination modes of these ligands were modified by addition of coordinating solvents such as water into the ethanolic ...
    • SYNTHESIS AND CHARACTERIZATION OF THE LAMELLAR OXYCHLORIDE CO2CU4TE4O11CL4 
      Ruiz León, Domingo; Spodine Spiridonova, Evgenia (Sociedad Chilena de Química, 2008-06)
      In this work we describe the synthesis and characterization of the Co2Cu4Te4O11Cl4 phase prepared by the hydrothermal technique. From the polycrystalline X-ray diffraction pattern the obtained new phase was indexed in the ...
    • Determination of polychlorinated biphenyls in biosolids using continuous ultrasound-assisted pressurized ... 
      Rocco, Gabriela; Toledo, Carla; Ahumada, Inés; Sepúlveda, Betsabet; Cañete, Alvaro; Richter Duk, Pablo (ELSEVIER SCIENCE BV, 2008-06-06)
      An efficient continuous pressurized solvent extraction (PSE) method assisted by ultrasound energy was developed for the extraction of polychlorinated biphenyls (PCBs) from biosolids. Analytes were determined in the ...
    • Glomalin-related soil protein in a Mediterranean ecosystem affected by a copper smelter and its contribution ... 
      Cornejo, Pablo; Meier, Sebastián; Borie B., Gilda; Rillig, Matthias C.; Borie, Fernando (ELSEVIER, 2008-11-15)
      The amount of glomalin-related soil protein (GRSP), a glycoprotein produced by arbuscular mycorrhizal fungi (AMF), its contribution to the sequestering of Cu and Zn in the soil, and the microsite variation of other soil ...
    • New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle 
      Porcal, Williams; Hernández, Paola; Boiani, Lucía; Boiani, Mariana; Ferreira, Ana; Chidichimo, Agustina; Cazzulo, Juan J.; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (Elsevier Ltd, 2008-07)
      Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically ...