Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 4601-4620 of 5193

    • Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR ... 
      Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)
      Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
    • Comparative evaluation of the acceptor properties of quinone derivatized polypyridinic ligands 
      Norambuena V., Ester; Olea Azar, Claudio; Delgadillo, Alvaro; Barrera, Mauricio; Loeb, Bárbara (ELSEVIER SCIENCE BV, 2009-05-18)
      The reduction properties of four acceptor polipyridyl ligands modified with quinones were studied by different experimental methods, as cyclic voltammetry and ESR spectroscopy, and by theoretical calculations. ESR spectra ...
    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 
      Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Computer assisted design of potentially active anti-trypanosomal compounds 
      Paulino, M.; Iribarne, F.; Hansz, M.; Vega, M.; Seoane, G.; Cerecetto, Hugo; Di Maio, R.; Caracelli, I.; Zukerman-Schpector, J.; Olea Azar, Claudio; Stoppani, A. O. M.; Berriman, M.; Fairlamb, A. H.; Tapia, O. (ELSEVIER SCIENCE BV, 2002-04-26)
      A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives. ...
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome ... 
      Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, ... 
      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Applications of electron spin, resonance and spin trapping in tropical parasitic diseases 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III 
      Cerecetto, Hugo; González, M.; Risso, Mariela; Saenz, P.; Olea Azar, Claudio; Bruno, A. M.; Azqueta, Amaia; De Cerain, A. L.; Monge, A. (WILEY-V C H VERLAG GMBH, 2004-05)
      New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...
    • Understanding the stereo- and regioselectivities of the polar Diels-Alder reactions between 2-acetyl-1,4- ... 
      Soto Delgado, Jorge; Domingo, L. R.; Araya Maturana, Ramiro; Contreras Ramos, Renato (JOHN WILEY & SONS LTD, 2009-06)
      The polar Diels-Alder (DA) reactions of 2-acetyl-1,4-benzoquinone (acBQ) with methyl substituted 1,3-butadienes have been studied using DFT methods at the B3LYP/6-31 G(d) level of theory. These reactions are characterized ...
    • 8,8-Diethyl-1,4,5,8-tetrahydronaphthalene-1,4,5-trione 
      Vega, Andrés; Ramírez Rodríguez, Oney; Martínez Cifuentes, Maximiliano; Ibáñez, Andrés; Araya Maturana, Ramiro (WILEY-BLACKWELL PUBLISHING, INC, 2009-02)
      The title molecule, C14H14O3, contains two fused six-membered carbon rings with keto groups at positions 1, 4 and 5 and a gem-diethyl group at position 8. The molecule is close to planar (maximum deviation = 0.044 angstrom), ...
    • Adsorption of ochratoxin A (OTA) anodic oxidation product on glassy carbon electrodes in highly acidic ... 
      Ramírez, Eduardo Alejandro; Zon, María Alicia; Jara Ulloa, Paola Andrea; Squella Serrano, Juan; Núñez Vergara, Luis; Fernández, Héctor (PERGAMON-ELSEVIER SCIENCE LTD, 2010-01-01)
      We study the thermodynamics and kinetics of the adsorption of a redox couple having quinone nature on glassy carbon electrodes. This couple is produced by the anodic oxidation of mycotoxin ochratoxin A in 10% acetonitrile ...
    • Rapid Capillary Electrophoresis Analysis of Glutathione and Glutathione Disulfide in Roots and Shoots of ... 
      Mendoza, Jorge; Garrido Reyes, Tatiana Inés; Riveros Salvatierra, Raúl; Parada Aliste, José (JOHN WILEY & SONS LTD, 2009-03)
      Introduction - Glutathione and glutathione disulfide can be determined by capillary zone electrophoresis; however, the frequent use of acidic precipitation of protein from samples prior to analysis generates an acidic ...
    • Two isomorphous crotonatolanthanide complexes: tetra-mu-but-2-enoato-bis[diaqua(but-2-enoato)Ln]-2,6-diaminopurine ... 
      Atria Salas, Ana María; Astete, Alan; Garland, María Teresa; Baggio, Ricardo (WILEY-BLACKWELL PUBLISHING, 2009-11)
      The title isomorphous compounds, tetra-mu-but-2-enoato-bis[diaqua(but-2-enoato)dysprosium(III)]-2,6-diaminopurine (1/2), [Dy-2(C4H5O2)(6)(H2O)(4)]center dot 2C(5)H(6)N(6), and tetra-mu-but-2-enoato-bis[diaqua(but-2-enoat ...
    • Oligo and polyuronic acids interactions with hypervalent chromium 
      González, J. C.; García, S. I.; Bellú, Sebastián; Atria Salas, Ana María; Salas Pelegrin, Juan Manuel; Rockenbauer, A.; Korecz, L.; Signorella, Sandra; Sala, Luis F. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-09-02)
      Selective oxidation of galacturonic residues of oligo and polyuronic acids by Cr-VI affords CO2/HCO2H, oxidized uronic acid, and Cr-III as final redox products. Kinetic studies show that the redox reaction proceeds through ...
    • Modification of poly(propylene) through grafting with dimethyl itaconate in solution 
      Yazdani-Pedram Zobeiri, Mehrdad; Vega, H.; Quijada Abarca, Juan (WILEY-V C H VERLAG GMBH, 1998-11)
      Functionalization of isotactic poly(propylene) (PP) with dimethyl itaconate (DMI) as functional polar monomer using 2,5-dimethyl-2,5 -bis(tert-butylperoxy)hexane (L101) as radical initiator was carried out in both boiling ...
    • Transparent semiconductor-polymer hybrid films with tunable optical properties 
      Martínez, Y.; Retuert de la Torre, Pedro Jaime; Yazdani-Pedram Zobeiri, Mehrdad; Coelfen, H. (ROYAL SOC CHEMISTRY, 2007)
      Size confined CdS nanoparticles with controlled size and narrow particle size distribution were synthesized in transparent adhesive polyelectrolyte films, which are composed of chitosan (CHI), poly( monomethyl itaconate) ...
    • A synthethic overview of new molecules with 5-HT 1A binding affinities 
      Pessoa Mahana, Hernán; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (Bentham Science Publishers, Ltd, 2003)
      The present review discusses the synthetic strategies of new ligands exhibiting mainly 5-HT1A binding affinities. Specifically we focused our attention in the synthesis of compounds structurally telated to arylpiperazine, ...
    • Synthesis of N-(morpholinomethyl) benzamides as moclobemide analogs 
      Pessoa Mahana, Hernán; Astudillo, C. I.; Araya Maturana, Ramiro (MARCEL DEKKER INC, 2002)
      Syntheses of new morpholinomethylbenzamides 6 bearing both electron-withdrawing and electron-releasing groups at the aromatic ring are described. The strategy involved synthesis of hippuric acid ethyl esters 3, their ...
    • Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: ... 
      Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)
      New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
    • Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action 
      Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Araya Maturana, Ramiro; Kosche Cárcamo, Johann Albert; Pessoa, D. (MARCEL DEKKER INC, 2004-07)
      We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual ...