Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

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    • Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free ... 
      Porcal, Williams; Hernández, Paola; González, Mercedes; Ferreira, Ana; Olea Azar, Claudio; Cerecetto, Hugo; Castro, Ana (American Chemical Society, 2008-09)
      New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative ...
    • Advanced cutaneous malignant melanoma: A systematic review of economic and quality-of-life studies 
      Cashin, Richard P.; Lui, Philip; Machado, Marcio; Hemels, Michiel E. H.; Corey-Lisle, Patricia K.; Einarson, Thomas R. (BLACKWELL, 2008-04)
      Objective: Metastatic melanoma (MM), a major concern for health-care providers, is increasing. We systematically reviewed published articles describing the impact of interventions (drugs and screening) on quality of life ...
    • Oil distribution in potato slices during frying 
      Pedreschi, Franco; Cocio, Claudia; Moyano, Pedro; Troncoso, Elizabeth (ELSEVIER SCI LTD, 2008-07)
      The objective of this research was to study the kinetics of oil absorption and distribution in the structure of potato slices during frying, considering the effects of three oil temperatures and a blanching pre-treatment. ...
    • Electrochemical behavior of copper complexes with substituted polypyridinic ligands: An experimental and ... 
      Cañón Mancisidor, Walter Alberto; Spodine Spiridonova, Evgenia; Venegas Yazigi, Diego; Rojas, Darío; Manzur Saffie, Jorge; Alvarez, Santiago (AMER CHEMICAL SOC, 2008-05-05)
      Experimental redox potentials of the couples [Cu(R-L-n)(CH3CN)](2+,+), where L-1 is bis-(pyridine-2-ylmethyl)-benzylamine, L-2 is (pyridine-2-ylethyl)(pyridine-2-ylmethyl)-benzylamine, and R is H, Me, or CF3, were determined ...
    • STABILITY STUDY OF PRAVASTATIN UNDER HYDROLYTIC CONDITIONS ASSESSED BY HPLC 
      Brain Isasi, S.; Requena, C.; Álvarez Lueje, Alejandro (SOC CHILENA QUIMICA, 2008-12)
      In this work all HPLC stability-indicating method was developed and applied to study the hydrolytic behavior of pravastatin in different pi-Is and temperatures. From the system suitability test, the selected chromatographic ...
    • SOLUBILIZATION OF DPPC SMALL UNILAMELLAR LIPOSOMES BY SUCROSE ESTERS. A FLUORESCENCE STUDY 
      Berríos, Eduardo; Zanocco Loyola, Antonio; Lemp Miranda, Else; Günther Sapunar, Germán (SOC CHILENA QUIMICA, 2008-12)
      The effect of the microenvironment on the Laurdan fluorescence was employed to study the solubilization mechanism of Dipalimtoyl-sn-glycero-3-phosphocholine (DPPC) small unilamellar vesicles with several sucrose monoesters. ...
    • Locus coeruleus mediates cold stress-induced polycystic ovary in rats 
      Bernuci, Marcelo P.; Szawka, Raphael E.; Helena, Cleyde V. V.; Leite, Cristiane M.; Lara Peñaloza, Hernán; Anselmo Franci, Janete A. (ENDOCRINE SOC, 2008-06)
      Previous reports about the rat ovary have shown that cold stress promotes ovarian morphological alterations related to a polycystic ovary (PCO) condition through activation of the ovarian sympathetic nerves. Because the ...
    • ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes 
      Otero, Lucía; Folch, Christian; Barriga, Germán; Rigol Olsen, Carolina; Opazo, Lucía; Vieites, Marisol; Gambino, Dinorah; Cerecetto, Hugo; Norambuena, Ester; Olea Azar, Claudio (Elsevier B.V., 2008-08)
      Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen ...
    • Characterization of micelles formed by sucrose 6-O-monoesters 
      Becerra, N.; Toro, C.; Zanocco Loyola, Antonio; Lemp Miranda, Else; Günther Sapunar, Germán (ELSEVIER, 2008-09-15)
      In the present study we synthesized and purified several 6-O-sucrose monoesters by using classical synthetic methods and stereo-regioselective procedures. The compounds have different alkyl chain lengths, with the number ...
    • The stereoselective synthesis of the Werner complex with substoichiometric sugars 
      Parada Aliste, José; Larrazábal Rojas, Guillermo; Aguirre Álvarez, Pedro; Zolezzi Carvallo, Santiago; Vega, Carmen; Garrido, Cristián (Sociedad Chilena de Química, 2008)
      A tetranuclear complex of Co(III) with hydroxo bridges, so-called “Werner Complex”, was synthesized in the presence of several sugars (1-8) with partial resolution of this complex. The sugars in 10 mol % with respect to ...
    • Lipid damage in farmed rainbow trout (Oncorhynchus mykiss) after slaughtering and chilled storage 
      Ortiz Viedma, Jaime; Palma, Oscar; González, Natalia; Aubourg, Santiago P. (WILEY-V C H VERLAG GMBH, 2008-12)
      The flow ice system including ozone (OFI condition) was tested for slaughtering and storage (up to 16 days) of farmed rainbow trout (Oncorhynchus mykiss). Lipid damage analyses were carried out and compared to sensory ...
    • How Changes in the Sequence of the Peptide CLPFFD-NH2 Can Modify the Conjugation and Stability of Gold ... 
      Olmedo, Ivonne; Araya, Eyleen; Sanz, Fausto; Medina, Elias; Arbiol, Jordi; Toledo, Pedro; Álvarez Lueje, Alejandro; Giralt, Ernest; Kogan Bocian, Marcelo (American Chemical Society, 2008-05-30)
      In a previous work, we studied the interaction of -amyloid fibrils (A ) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the ...
    • ESR, electrochemical and cyclodextrin-inclusion studies of triazolopyridyl pyridyl ketones and dipyridyl ... 
      Olea Azar, Claudio; Abarca, B.; Norambuena, Ester; Opazo, L.; Jullian Matthaei, Carolina; Valencia, S.; Ballesteros, R.; Chadlaoui, M. (Elsevier B.V., 2008-11)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic reduction of triazolopyridyl pyridyl ketones and dipyridyl ketones derivatives were measured in dimethylsulfoxide (DMSO). The hyperfine ...
    • Antinociceptive activity of Buddleja globosa (matico) in several models of pain 
      Backhouse Erazo, Nadine; Delporte Vergara, Carla; Apablaza, Cecia; Farías, Mariela; Goity Vivar, León Eduardo; Arrau, Sylvia; Negrete Córdova, Rosa; Castro, Consuelo; Miranda, Hugo (2008-09-02)
      Ethnopharmacological relevance: Leaf extracts of Buddleja globosa (Buddlejaceae) are used in Chilean folk medicine for wound healing. The anti-inflammatory (topic and per as), analgesic (per os) effects and the antioxidant ...
    • Analgesic, anti-inflammatory and antioxidant properties of Buddleja globosa, Buddlejaceae 
      Backhouse Erazo, Nadine; Rosales, L.; Apablaza, Cecia; Goity Vivar, León Eduardo; Erazo, S.; Negrete Córdova, Rosa; Theodoluz, C.; Rodríguez, J.; Delporte Vergara, Carla (ELSEVIER IRELAND LTD, 2008-03-05)
      Abstract: Ethnopharmacological relevance: Buddleja globosa, known as "matico", is employed in Chile for wound healing. Aim of the study: To validate the traditional use of the crude drug through in vivo and in vitro ...
    • [2-(2-{Bis[2-(1H-imidazol-2-ylmethyl-eneamino)ethyl] amino} ethylimino-methyl) imidazolido] cobalt(III) ... 
      Atria Salas, Ana María; Corsini, Gino; Talamilla, Arlyn; Garland, María Teresa; Baggio, Ricardo (BLACKWELL, 2008-12)
    • Photophysics and Photochemistry of Naphthoxazinone Derivatives 
      Nonell, Santi; Ferreras, Lourdes R.; Cañete, Alvaro; Lemp Miranda, Else; Günther Sapunar, Germán; Pizarro, Nancy; Zanocco Loyola, Antonio (AMER CHEMICAL SOC, 2008-07-18)
      The photophysics and photochemistry of a series of naphthoxazinones have been studied using a combination of methods ranging from steady-state and time-resolved spectroscopic techniques to product analysis. The photophysics ...
    • Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis 
      Araya, Eyleen; Olmedo, Ivonne; Bastus, Neus G.; Guerrero, Simón; Puntes, Víctor F.; Giralt, Ernest; Kogan Bocian, Marcelo (SPRINGER, 2008-11)
      Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
    • Current-status survival analysis methodology applied to estimating sensory shelf life of ready-to-eat lettuce ... 
      Araneda, Mabel; Hough, Guillermo; Wittig Rovira, Emma (BLACKWELL, 2008-04)
      The objective of the present work was to develop a method for predicting sensory shelf life for situations in which each consumer evaluates only one sample corresponding to one storage time. This type of data is known as ...
    • Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes 
      Navarro, Paola; Chiong Lay, Mario; Volkwein, Karen; Moraga, Francisco; Ocaranza, María Paz; Jalil Milad, Jorge; Sun, Woo Lim; Jeong-Ah, Kim; H., Moo Kwon; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-07-25)
      Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key ...