ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes
Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen palladium complexes grouped in two series of the formula [PdCl2HL] or [PdL2] were studied. ESR spectra of the free radicals obtained by electrolytic reduction were characterized and analyzed. The ESR spectra showed two different hyperfine patterns. The stoichiometry of the complexes does not seem to affect significantly the hyperfine constants however we observed great differences between 5-nitrofurane and 5-nitrofurylacroleine derivatives. The scavenger properties of this family of compounds were lower than Trolox.
This research was supported by FONDECYT 1071068 grant (Chile), CSIC and PDT 10002-04 (Uruguay) and TWAS 04-205 RG/CHE/LA grant.
Quote ItemSpectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 70, Issue 3,, Pages 519-523, 2008