Now showing items 751-770 of 4968

    • Pinto Jiménez, Manuel; Robledo Veloso, Gonzalo (2011)
      A novel method to construct the fundamental matrix for a linear almost periodic system is proposed, provided that the diagonal terms satisfy an average separation condition and the off-diagonal coefficients are L∞- small. ...
    • Oyarce, César; Cruz Gómez, Sebastián; Gálvez Cancino, Felipe Ignacio; Vargas, Pablo; Moreau, Hélène D.; Díaz Valdivia, Natalia; Díaz, Jorge; Salazar Onfray, Flavio; Pacheco, Rodrigo; Lennon Duménil, Ana María; Quest, Andrew F. G.; Lladser, Álvaro (Frontiers Media, 2017)
      Dendritic cell (DC) trafficking from peripheral tissues to lymph nodes (LNs) is a key step required to initiate T cell responses against pathogens as well as tumors. In this context, cellular membrane protrusions and the ...
    • Rodríguez, Diego A.; Tapia, Julio; Fernández, Jaime G.; Torres Gómez, Vicente; Muñoz, Nicolás; Galleguillos, Daniela; Leyton Campos, Lisette; Quest, Andrew F. G. (2009)
      Augmented expression of cyclooxygenase-2 (COX-2) and enhanced production of prostaglandin E2 (PGE2) are associated with increased tumor cell survival and malignancy. Caveolin-1 is a scaffold protein that has been proposed ...
    • Haas, Jan D.; Malinarich González, Frano H.; Schmitz, Susanne; Chennupati, Vijaykumar; Föhse, Lisa; Kremmer, Elisabeth; Förster, Reinhold; Prinz, Immo (2009)
      γδ T cells are a potent source of innate IL-17A and IFN-γ, and they acquire the capacity to produce these cytokines within the thymus. However, the precise stages and required signals that guide this differentiation are ...
    • Bono Merino, María Rosa; Fernández, Dominique; Flores Santibáñez, Felipe; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (Elsevietr, 2015)
      Extracellular ATP is a danger signal released by dying and damaged cells, and it functions as an immunostimulatory signal that promotes inflammation. However, extracellular adenosine acts as an immunoregulatory signal that ...
    • Briceño Catalán, Pedro Felipe; Rivas Yáñez, Elizabeth Camila; Rosemblatt Bono, Mariana Violeta; Parra Tello, Brian Josué; Farías, Paula; Vargas, Leonardo; Simon Zegers, María Valeska; Cárdenas, César; Lladser, Álvaro; Salazar Onfray, Flavio Andrés; Elorza, Álvaro A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela Macarena (Frontiers Media, 2021)
      CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown ...
    • Flores Santibáñez, Felipe; Fernández, Dominique; Meza, Daniel; Tejón, Gabriela; Vargas, Leonardo; Varela Nallar, Lorena; Arredondo, Sebastián; Guixé Leguía, Victoria Cristina; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Wiley & Sons, 2015)
      The CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in ...
    • Utreras Puratich, Elías; Henríquez, Daniel R.; Contreras Vallejos, Erick; Olmos, Cristina; Di Genova, Alex; Maass Sepúlveda, Alejandro; Kulkarni, Ashok B.; González Billault, Christian (2013)
      Rap1 signaling is important for migration, differentiation, axonal growth, and during neuronal polarity. Rap1 can be activated by external stimuli, which in turn regulates specific guanine nucleotide exchange factors such ...
    • Furusawa, Kotaro; Asada, Akiko; Urrutia, Pamela; González Billault, Christian; Fukuda, Mitsunori; Hisanaga, Shin-ichi (Society for Neuroscience, 2017)
      Neurons communicate with each other through their axons and dendrites. However, a full characterization of the molecular mechanisms involved in axon and dendrite formation is still incomplete. Neurite outgrowth requires ...
    • Noriega, Ximena; Pérez Correa, Francisco (Taylor & Francis, 2017)
      Single-bud cuttings of Vitis vinifera L exposed to forced growing conditions were used to investigate the involvement of phytohormones, abscisic acid (ABA), auxin (Aux) and cytokinin (CK) in the release of buds from the ...
    • Tapia, Julio; Bolanos-Garcia, Victor M.; Sayed, Muhammed; Allende, Catherine C.; Allende, Jorge E. (2004)
      The protein kinase CK2 is constituted by two catalytic (α and/or α′) and two regulatory (β) subunits. CK2 phosphorylates more than 300 proteins with important functions in the cell cycle. This study has looked at the ...
    • Urrutia, Pamela J.; Aguirre, Pabla; Tapia, Victoria; Carrasco, Carlos M.; Mena, Natalia P.; Núñez González, Marco (Elsevier, 2017)
      Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises as to whether ...
    • Zeiger, Eduardo; Cardemil, Liliana (1973)
      Cell kinetics parameters were obtained for the three mitotic divisions leading to formation of stomata in the epidermis of the cotyledon of Allium cepa seedlings. Analysis of mitotic frequencies throughout the course of ...
    • Castillo, Karen; Restrepo, Diego; Bacigalupo Vicuña, Juan (2010)
      Signal transduction depends critically on the spatial localization of protein constituents. A key question in odor transduction is whether chemotransduction proteins organize into discrete molecular complexes throughout ...
    • González, Andrés; Moya Alvarado, Guillermo; González Billault, Christian; Bronfman, Francisca (Wiley, 2016)
      Brain-derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic and axonal growth during development and maintenance of the mature nervous system; however, the cellular and molecular mechanisms ...
    • Vidal, René L.; Valenzuela, José I.; Luján, Rafael; Couve Correa, Andrés (2009)
      Background: Marlin-1 is a microtubule binding protein that associates specifically with the GABAB1 subunit in neurons and with members of the Janus kinase family in lymphoid cells. In addition, it binds the molecular motor ...
    • Varas, A.; Cornejo, M. D.; Mainemer, D.; Toledo Cabrera, Benjamín; Rogan Castillo, José; Muñoz Gálvez, Víctor; Valdivia Hepp, Juan (2007)
      A bidimensional cellular automaton model is used to simulate the process of evacuation of pedestrians in a room with fixed obstacles. A floor field is defined so that moving to a cell with lower floor field means approaching ...
    • Nicolas, M. T.; Barhanin, J.; Reyes, R.; Demêmes, D. (Elsevier, 2003)
      K+ channels in the inner ear regulate the secretion and homeostasis of K+, i.e. the flux of K+ ions required to ensure good mechanosensory transduction. We studied the expression and cellular localization of TWIK-1 and ...
    • Guthman, Ethan; Vera Buschmann, Jorge (Soc. Neuroscience, 2016)
    • Li, Hongjiang; Wangenheim, Daniel von; Zhang, Xixi; Tan, Shutang; Darwish-Miranda, Nasser; Naramoto, Satoshi; Wabnik, Krzysztof; De Rycke, Riet; Kaufmann, Walter A.; Gütl, Daniel; Tejos, Ricardo; Grones, Peter; Ke, Meiyu; Chen, Xu; Dettmer, Jan; Friml, Jiri (Wiley, 2020)
      Cell and tissue polarization is fundamental for plant growth and morphogenesis. The polar, cellular localization ofArabidopsisPIN-FORMED (PIN) proteins is crucial for their function in directional auxin transport. The ...