Now showing items 330-349 of 2801

    • Trincado, Valeria; Gala, Rikhav P.; Morales Montecinos, Javier Octavio (MDPI, 2021)
      Currently, most vaccines available on the market are for parental use; however, this may not be the best option on several occasions. Mucosal routes of administration such as intranasal, sublingual, and buccal generate ...
    • Ortiz A.C., Morales J.O. (Springer, 2020)
    • Morales Montecinos, Javier; Brayden, David J. (Elsevier, 2017)
      Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of ...
    • Montero-Padilla, Soledad; Velaga, Sitaram; Morales, Javier O. (Springer New York LLC, 2017)
      © 2016, American Association of Pharmaceutical Scientists. The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that ...
    • Sapag Hagar, Mario (Universidad de Chile, 1997)
      Cuando Platón regresó a Atenas en el año 387 a.C., se estableció una escuela de filosofía en un jardín, a poco más de 1 Km. de distancia de la ciudad, con olivos, estatuas y templos, denominado Academos, en honor a su ...
    • Vicencio, José Miguel; Lavandero González, Sergio; Szabadkai, Gyorgy (ELSEVIER, 2010)
      Substantial progress has been made throughout the last decades in the elucidation of the key players and mechanisms responsible for Ca2+ signal generation in both excitable and non-excitable cells. Importantly, these ...
    • González, F.; Silva, M.; Schalscha B., Eduardo; Alay, F. (SPRINGER VERLAG, 1998-01)
      Heavy metals participate in complex biogeochemical cycles whose final destination (except on a geological scale)is the bottom of oceans and lakes. This implies that to reach the bottom the metals of the sediment have to ...
    • Vergara, I.; Schalscha B., Eduardo (Universita degli Studi di Pisa, Istituto di Chimica Agraria, 1992)
      Wasterwastes of municipal and industrial origin used to irrigate farmlands contain heavy metals which are sorbed on the surfaces of soil particles. Among those metals are cadmium (Cd) and copper(Cu). The degree to which ...
    • Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Morales, Bernardo; Madrid, Rodolfo; Bacigalupo Vicuña, Juan (1997)
      In toad olfactory neurons, a putrid odorant mixture inducing inhibitory responses increases Ca2+-activated K+ conductance, developing a hyperpolarizing receptor potential. Removal of extracellular Ca2+ or exposure to ...
    • Bravo Sagua, Roberto; Parra Ortíz, María Valentina; López Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero González, Sergio (Wiley, 2017-04)
      Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
    • Fuenzalida, Lucía; Alfaro Román, Raquel; Wittig Rovira, Emma (Sociedad Chilena de Nutrición, Bromatología y Tecnología, 1982)
      The evaluation of the sensorial quality of tea was developed in order to complement the information obtained from physico-chemical analysis performed on different types of tea. The work was carried on with 12 samples, ...
    • Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Ahumada Torres, Aída Inés de Lourdes; Schalscha B., Eduardo; Soto, R. (SOCIEDAD CHILENA DE QUIMICA, 1997-12)
      The applicability, sensitivity and repetitivity, as well as general aspects of the Capillary Zone Electrophoresis (CZE) technique was studied as applied in the identification and quantification of Cl-, NO3-, HCO3-, SO42-, ...
    • Larraín Barth, María Angélica; Abugoch James, Lilian; Quitral Robles, Vilma; Vinagre, Julia; Segovia, C. (ELSEVIER SCI LTD, 2002-03)
      Capillary zone electrophoresis (CZE) was used to study the effect of frozen storage on the electrophoretic patterns of sarcoplasmic proteins (SAR) extracted from fillets of golden kinglip (Genypterus blacodes) species using ...
    • Riveros, A. L.; Astudillo, J.; Vásquez, C.; Jara, Danilo; Guerrero Hernández, Ariel; Gúzman, F.; Osorio Román, Igor; Kogan Bocian, Marcelo (Springer, 2016)
      Highly fluorescent nanoparticles, or quantum dots, have multiple applications in biology and biomedicine; however, in most cases, it is necessary to functionalize them to enhance their biocompatibility and selectivity. ...
    • Mena, Juan F.; Neira Carrillo, Andrónico; Yazdani-Pedram Zobeiri, Mehrdad; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      With the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and ...
    • Castro Castillo, Vicente; Gajardo, Javier; Sandoval Altamirano, Catalina; Gratton, Enrico; Sánchez, Susana; Malacrida, Leonel; Gunther, German (Royal Society of Chemistry, 2020)
      We synthesized an anthracene derivative with solvatochromic properties to be used as a molecular probe for membrane dynamics and supramolecular organization. A nine carbon atom acyl chain and a dimethylamino substitution ...
    • Masson Salaué, Lilia; Camilo Manríquez, Conrado; Torija, M. Esperanza (INST GRASA SUS DERIVADOS, 2008-01)
      Se analizan las características generales del coquito de palma chilena y se estudia con detalle la composición de su aceite. Con este objetivo, se analizan 4 lotes de coquitos procedentes de las dos regiones de Chile ...
    • Salgado Figueroa, Paola; Gutiérrez, C.; Squella Serrano, Juan (Elsevier, 2015)
      tA simple and sensitive electrochemical method using pretreated carbon nanofiber screen printed elec-trodes joined to a flow injection analysis (CNF-SPE-FIA) system was developed to analyze nimodipine(NMD) in pharmaceutical ...