Browsing by Author "Pessoa Mahana, Hernán"
Now showing items 1-20 of 24
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Vásquez, David; Lagos González, Carlos F.; Mella Raipán, Jaime A.; González, Luis; Ebensperger González, Roberto; Alvarez Figueroa, M. Javiera; Sáez, Edmundo; Pessoa Mahana, Hernán; Araya Secchi, Raúl; González Wong, Angel; Pérez-Acle, Tomás; Pessoa, D. (SOC CHILENA QUIMICA, 2007-12)A novel approach to the development of anew class of HIV-1 RT inhibitors is reported. The 1-benzoyl-2-aryl-1H-benzimidazole series was designed as a combination of two previously reported active scaffolds, the benzimidazole ...
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Araya Maturana, Ramiro; Heredia Moya, Jorge; Pessoa Mahana, Hernán; Weiss López, Boris; Muñoz, J. C. (BLACKWELL MUNKSGAARD, 2005-04)The title compound, C12H7NO3, consists of a chromone moiety substituted in position 3 with an acrylonitrile group in a Z configuration. The two planar groups are twisted with respect to one another. The only significant ...
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Valderrama, Jaime A.; Pessoa Mahana, Hernán; Sarras, Gabriela; Tapia, Ricardo (1999)A synthesis of N-(2-nitrobenzyl)acetanilide (5) and (11) from 2- nitrobenzaldehyde and aromatic amines is reported. The reaction of amides (5) and (11) with iron in acetic acid-ethanol-water provided the corresponding 3- ...
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Weiss López, Boris; Jullian Matthaei, Carolina; Saitz Barría, Claudio; Pessoa Mahana, Hernán; Valderrama, J.; Araya Maturana, Ramiro (SOCIEDAD CHILENA DE QUIMICA, 2001-09)Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2'-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d(6), were measured employing the temperature ...
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Mella Raipán, Jaime A.; Lagos, Carlos F.; Recabarren Gajardo, Gonzalo Iván; Espinosa Bustos, Christian; Romero Parra, Javier; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David (2013)A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 ...
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Espinosa Bustos, Christian; Lagos, Carlos F.; Romero Parra, Javier; Zárate, Ana M.; Mella Raipán, Jaime A.; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Iturriaga-Vásquez, Patricio; Tapia, Ricardo A.; Pessoa Mahana, Carlos David (Wiley-VCH Verlag, 2015)© 2015 Wiley-VCH Verlag GmbH & Co. KGaA. A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand ...
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Araya Maturana, Ramiro; Heredia Moya, Jorge; Donoso Tauda, Oscar; Vera Castillo, Mario Francisco; Toledo Hernández, Jorge; Pavani, Mario; Pessoa Mahana, Hernán; Weiss López, Boris; Ferreira Parker, Jorge (NATURAL PRODUCTS INC, 2008)A set of structurally related compounds incorporating a chromone moiety as an essential component of their structures were tested against the TA3 mouse carcinoma cell line and its multidrug-resistant variant TA3-MTX-R. A ...
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Pessoa Mahana, Hernán; Martínez Aranguiz, Gracia Karen; Araya Maturana, Ramiro; Pessoa, D. (TAYLOR & FRANCIS INC, 2005)The synthesis of new eight-membered cycle dibenzo[b,f][1,5]-diazocine-6(5H)-one derivatives 11, 12 was developed. The key step in this synthesis was the intramolecular cyclization of the amino aldehyde precursors 9,10 ...
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Araya Maturana, Ramiro; Gavin Sazatornil, J. A.; Heredia Moya, Jorge; Pessoa Mahana, Hernán; Weiss López, Boris (SOC BRASILEIRA QUIMICA, 2005-05)A systematic study about the long-range correlations observed in the HMBC spectra of a series of cis and trans 3-(4-oxo-4H-chromen-3-yl)-acrylic acid ethyl esters, and 5-hydroxy derivatives, was carried out. The results ...
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Fuente, J. de la; Jullian Matthaei, Carolina; Saitz Barría, Claudio; Sobarzo Sánchez, Eduardo; Neira Pacheco, Verónica Alejandra; González, C.; López, R.; Pessoa Mahana, Hernán (ROYAL SOC CHEMISTRY, 2004)Photoreduction of 5,6-dimethoxy-, 5-methoxy- and 2,3-dihydro-7H-dibenzo[de, h] quinolin-7-one (A) by tertiary amines in oxygen-free solutions generates long-lived semi-reduced metastable photoproducts, A - NH-, via a ...
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Pessoa Mahana, Hernán; Kosche Cárcamo, Johann; Ron Higuera, Nadia; Recabarren Gajardo, Gonzalo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa Mahana, Carlos (2008)A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
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Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa, D.; Araya Maturana, Ramiro; Ron Higuera, Nadia Betsabé; Saitz Barría, Claudio (ARKAT USA INC, 2009)A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b] thiophen-2 ...
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Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa Mahana, David; Araya Maturana, Ramiro; Ron, Nadia; Saitz Barría, Claudio (Arkat, 2009)A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b]thiophen-2- ...
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Pessoa Mahana, Hernán; Pessoa, D.; Salazar González, Ricardo Andrés; Valderrama Guerrero, Jaime Adolfo; Sáez, Edmundo; Araya Maturana, Ramiro (GEORG THIEME VERLAG KG, 2004-02-18)The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives 5-9 and their reduction to the corresponding 2-benzimidazoylbenzamides 10-13 are described. Compounds 10-13 were cleanly and efficiently converted ...
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Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter Ojeda Gómez, Claudia; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David; Recabarren Gajardo, Gonzalo Iván; Méndez Rojas, Claudio (Wiley, 2014)A series of functionalized indolylalkylarenes 3–16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3–12(a and b) were obtained by nucleophilic substitution ...
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Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
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Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene ...
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Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Araya Maturana, Ramiro; Kosche Cárcamo, Johann Albert; Pessoa, D. (MARCEL DEKKER INC, 2004-07)We report here the synthesis of substituted 4-chloro-N-[3-oxo-3-(4-aryl-1-piperazinyl)-propyl] benzamides (5-9), as potential new antidepressants, incorporating in a single molecule structural moieties related to a dual ...
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Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
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Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Moris, S.; Jara, P.; Fuente, Julio de la; Pessoa Mahana, Hernán; Jullian Matthaei, Carolina; Saitz, C. (Elsevier, 2017)A new calix[4]arene thiourea derivative bearing a benzothiazolyl moiety (L) was synthetized and characterized by single crystal X-ray, NMR and ESI-TOF. The binding ability of the bifunctional receptor towards several ions ...