Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs

Abstract

A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene carbonyl chloride (5) with a series of substituted 4-arylpiperazines.