Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b] thiophen-2-yl-2-propenone

Abstract

A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b] thiophen-2-yl)-2-propen-1-one (4), to produce beta-aminoketones and azaheterocyclic compounds of potential biological interest.