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Frame-shifts of digit identity in bird evolution and Cyclopamine-treated wings

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2009-03
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Vargas, Alexander O.
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Frame-shifts of digit identity in bird evolution and Cyclopamine-treated wings
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  • Vargas, Alexander O.;
  • Wagner, Günter P.;
Abstract
A highly conserved spatio-temporal pattern of cartilage formation reveals that the digits of the bird wing develop from positions that become digits 2, 3, and 4 in other amniotes. However, the morphology of the digits of early birds like Archaeopteryx corresponds to that of digits 1, 2, and 3 of other archosaurs. A hypothesis is that a homeotic ‘‘frameshift’’ occurred, such that in the bird wing, digits 1, 2, and 3 develop from the embryological positions of digits 2, 3, and 4. Experimental homeotic transformations of single digits are well-documented, but frame-shifts of more than one digit are not. We investigated the pattern of cartilage formation in the development of Cyclopamine-treated wings. When Cyclopamine was applied between stages 18 and 21, morphologies that normally develop from positions 2 and 3 developed from positions 3 and 4. The serial shift of digit identity toward posterior confirms a mechanistic possibility that was previously inferred from the evolutionary history of birds.
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This research was supported by NSF grant IOB-0445971 to G. P. W. and a Pew Latin American Fellowship to A. V.
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URI: https://repositorio.uchile.cl/handle/2250/119190
ISSN: 1520-541X
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EVOLUTION & DEVELOPMENT, Volume: 11, Issue: 2, Pages: 163-169, 2009
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