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Surface-Enhanced Raman Scattering and Theoretical Studies of the C-Terminal Peptide of the beta-Subunit Human Chorionic Gonadotropin Without Linked Carbohydrates

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2011-09-08
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Aliaga, A. E.
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Surface-Enhanced Raman Scattering and Theoretical Studies of the C-Terminal Peptide of the beta-Subunit Human Chorionic Gonadotropin Without Linked Carbohydrates
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Author
  • Aliaga, A. E.;
  • Aguayo, T.;
  • Garrido, C.;
  • Clavijo Campos, Ernesto;
  • Hevia, E.;
  • Gómez Jeria, Juan;
  • Leyton, P.;
  • Campos Vallette, Marcelo;
  • Sánchez Cortés, S.;
Abstract
Raman and surface-enhanced Raman scattering (SERS) spectra of the synthetic carboxy terminal peptide of human chorionic gonadatropin b-subunit free of carbohydrate moieties (P37) are reported. The spectral analysis is performed on the basis of our reported Raman spectrum and SERS data of oligopeptides displaying selected amino acids sequences MRKDV, ADEDRDA, and LGRGISL. SERS samples of P37 were prepared by coating the solid peptide with metal colloids on a quartz slide. This treatment makes possible to obtain high spectral batch to batch reproducibility. Amino acids components of P37 display net charges and hydrophobic characteristics, which are related to particular structural aspects of the adsorbate–substrate interaction. The spectroscopic results are supported by quantum chemical calculations performed by using extended Hu¨ckel theory method for a model of P37 interacting with an Ag surface. The P37-metal interaction is drove by positively charged fragments of selected amino acids, mainly threonine 109, lysine 122, and arginine in positions 114 and 133. Data here reported intend to contribute to the knowledge about the antigen–antibody interaction and to the drugs delivery research area.
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Contract grant sponsor: CSIC-CONICYT Contract grant number: 2007-145 Contract grant sponsors: Fondecyt Contract grant number: 1070078, 1085124, and 1090074 Contract grant sponsors: Ministerio de Educacio´n y Ciencia of Spain Contract grant number: FIS2007-63065 Contract grant sponsors: Comunidad de Madrid Contract grant number: S2009/TIC-1476 MICROSERES II Contract grant sponsors: Doctoral Fellowship CONICYT (to A.E.A.) Contract grant number: AT-24090050 (to A.E.A.)
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URI: https://repositorio.uchile.cl/handle/2250/119318
ISSN: 0006-3525
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BIOPOLYMERS, Volume: 95, Issue: 2, Pages: 135-143, 2011
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