Monoaminergic, Ion Channel and Enzyme Inhibitory Activities of Natural Aporphines, their Analogues and Derivatives

Abstract

The aporphine alkaloids constitute the second-largest group of isoquinoline alkaloids. Nevertheless, only a relatively small number of natural aporphines and their derivatives have been studied from a pharmacological viewpoint. Here we review the pharmacological data available for these compounds as related to their dopaminergic, noradrenergic and serotonergic activities, and also some results pertaining to their effects on ion channels and enzymes.