A two-step method for the preparation of homochiral cathinones
Osorio_O_Mauricio.pdf (200.2Kb)Abstract
Abstract—A simple method for the preparation of homochiral ring-substituted 1-aryl-2-aminopropanones 2 (‘cathinones’) is
described, involving initial Friedel–Crafts acylation of aromatics with (S)- or (R)-N-trifluoroacetylalanyl chloride, followed by
acid hydrolysis of the intermediate trifluoroacetamido intermediates 1, for which X-ray diffraction analysis confirmed the
structures.
Patrocinador
This work was supported by FONDECYT Grant Nos.
1000776 and 1020802, FONDAP Grant No. 11980002
Fundacio´n Andes (C-13575) and USACH-DICYT.
J.C.M.-A. is a grateful recipient of a DAAD scholarship,
and M.O.-O. of CONICYT and MECESUP
(USA 9903) scholarships.
Quote Item
Tetrahedron: Asymmetry Vol. 14, p. 1473–1477, 2003.
Collections