THE PREPARATION OF POTENTIALLY PSVCHOACTIVE ~-ALKOXVPHENETHVLAMINES

Abstract

üThe preparal.1on of B-alkoxYPhenethylamlne~ 3 lS described. As part of our ¡nteresl. in structure-actlvlty relatlonshtps of O$'~c.hl)tomimetic phenethylamínes I ond their ínteroctíons with serol.Onlnergic receptors 2, we describe In ttle present communlcatlon tne preparetlOn (If a series oi substttuted ~-alkoxYPhenylethylemines. A few of these compounds hod been prepered before 3,4 end theír psychotropic properties described with humen volunteers, However, ru) PMrrrll'JC')logiclIl sludies on ttlese new compoUnds heve been cerrleo out Slnee fhen, asida from the fey.¡ instances in which 8 (i-methoxylated derivative has shown a potency similar to or slightJy greater than that of lhe (,orent compound Little ís known about t.he effects of substitution at. the !\-p(l~1tl0n (\1 tn~ Sld~ CMm of nel1uClnogeníc phenethylemiMS. elthough 1t. .,y,jS :.peCIJleted lhet the!r ectivity might