Nitro Radical Anion Formation from Nitro-8ubstituted Amphetamine Derivatives
The cyclic voltammetric characteristics of two nitroamphetamine derivatives (2-nitro-4,5dimethoxyamphetamine and 2-nitro-4,5-methylenedioxyamphetamine) have been investigated in different media. In mixed media (aqueous buffer and DMF, dioxane, or acetonitrile) a reversible oneelectron reduction takes place to form a stable nitro radical anion. At more negative potential values, a further three-electron reduction occurs irreversibly to give the hydroxylamine derivative. Cyclic voltammetry (CV) has been employed to study the tendency of the nitro radical anions to undergo further chemical reactions. The subsequent chemical reaction corresponds to a second-order process, a dismutation reaction electrochemically initiated. Data about rate constantS and half-life times in mixed media are reported.
Tbis work was partiall)' supported by grants Irom FONDECYT (91/0881) and DTI Universidad de Chile (Q-3118/9223).
Quote ItemElectroanalysis, Vol. 6, p. 509-513, 1994