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Synthesis of new 4-nitrosophenyl-1,4-dihydropyridines of pharmacological interest

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2003-12-18
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Santander Gutierrez, Ingrid Paola
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Synthesis of new 4-nitrosophenyl-1,4-dihydropyridines of pharmacological interest
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  • Santander Gutierrez, Ingrid Paola;
  • Núñez Vergara, Luis;
  • Squella Serrano, Juan;
  • Navarrete Encina, Patricio;
Abstract
The synthesis and characterization of a series of 4-nitrosophenyl-1.4-dihydropyridines derived from the respective nitro compounds of pharmacological interest is described. The complete synthetic pathway is based on the classical Hantzsch 1,4-dihydropyridine synthesis to obtain the nitrophenyl 1,4-dihydropyridines in a first step, followed by chemical reduction of the nitro compound to the corresponding hydroxylamine and further oxidation to the nitroso derivative. The synthesis and characterization of the compounds is described.
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URI: https://repositorio.uchile.cl/handle/2250/121311
ISSN: 0039-7881
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SYNTHESIS-STUTTGART Nº 18 Pages: 2781-2784
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