Show simple item record

Authordc.contributor.authorTheil, Elizabeth C. 
Authordc.contributor.authorChen, Huijun es_CL
Authordc.contributor.authorMiranda, Constanza es_CL
Authordc.contributor.authorJanser, Heinz es_CL
Authordc.contributor.authorElsenhans, Bernd es_CL
Authordc.contributor.authorNúñez González, Marco es_CL
Authordc.contributor.authorPizarro Aguirre, Fernando es_CL
Authordc.contributor.authorSchümann, Klaus es_CL
Admission datedc.date.accessioned2012-07-30T21:21:54Z
Available datedc.date.available2012-07-30T21:21:54Z
Publication datedc.date.issued2012-03
Cita de ítemdc.identifier.citationJOURNAL OF NUTRITION Volume: 142 Issue: 3 Pages: 478-483 Published: MAR 2012es_CL
Identifierdc.identifier.otherDOI: 10.3945/jn.111.145854
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/124015
General notedc.descriptionArtículo de publicación ISIes_CL
Abstractdc.description.abstractFerritin iron from food is readily bioavailable to humans and has the potential for treating iron deficiency. Whether ferritin iron absorption is mechanistically different from iron absorption from small iron complexes/salts remains controversial. Here, we studied iron absorption (RBC Fe-59) from radiolabeled ferritin iron (0.5 mg) in healthy women with or without non-ferritin iron competitors, ferrous sulfate, or hemoglobin. A 9-fold excess of non-ferritin iron competitor had no significant effect on ferritin iron absorption. Larger amounts of iron (50 mg and a 99-fold excess of either competitor) inhibited iron absorption. To measure transport rates of iron that was absorbed inside ferritin, rat intestinal segments ex vivo were perfused with radiolabeled ferritin and compared to perfusion with ferric nitrilotriacetic (Fe-NTA), a well-studied form of chelated iron. Intestinal transport of iron absorbed inside exogenous ferritin was 14.8% of the rate measured for iron absorbed from chelated iron. In the steady state, endogenous enterocyte ferritin contained >90% of the iron absorbed from Fe-NTA or ferritin. We found that ferritin is a slow release source of iron, readily available to humans or animals, based on RBC iron incorporation. Ferritin iron is absorbed by a different mechanism than iron salts/chelates or heme iron. Recognition of a second, nonheme iron absorption process, ferritin endocytosis, emphasizes the need for more mechanistic studies on ferritin iron absorption and highlights the potential of ferritin present in foods such as legumes to contribute to solutions for global iron deficiency.es_CL
Patrocinadordc.description.sponsorshipNIH DK20251 CHORI Foundation Fondecyt-Chile 1050068 Hildegard-Grunow-Foundationes_CL
Lenguagedc.language.isoenes_CL
Publisherdc.publisherAMER SOC NUTRITIONes_CL
Keywordsdc.subjectSOYBEAN FERRITINes_CL
Títulodc.titleAbsorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segmentses_CL
Document typedc.typeArtículo de revistaes_CL


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record