About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Instituto de Nutrición y Tecnología de los Alimentos
  • Artículos de revistas
  • View Item
  •   Home
  • Instituto de Nutrición y Tecnología de los Alimentos
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Absorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segments

Artículo
Thumbnail
Open/Download
IconTheil_Elizabeth.pdf (669.7Kb)
Publication date
2012-03
Metadata
Show full item record
Cómo citar
Theil, Elizabeth C.
Cómo citar
Absorption of Iron from Ferritin Is Independent of Heme Iron and Ferrous Salts in Women and Rat Intestinal Segments
.
Copiar
Cerrar

Author
  • Theil, Elizabeth C.;
  • Chen, Huijun;
  • Miranda, Constanza;
  • Janser, Heinz;
  • Elsenhans, Bernd;
  • Núñez González, Marco;
  • Pizarro Aguirre, Fernando;
  • Schümann, Klaus;
Abstract
Ferritin iron from food is readily bioavailable to humans and has the potential for treating iron deficiency. Whether ferritin iron absorption is mechanistically different from iron absorption from small iron complexes/salts remains controversial. Here, we studied iron absorption (RBC Fe-59) from radiolabeled ferritin iron (0.5 mg) in healthy women with or without non-ferritin iron competitors, ferrous sulfate, or hemoglobin. A 9-fold excess of non-ferritin iron competitor had no significant effect on ferritin iron absorption. Larger amounts of iron (50 mg and a 99-fold excess of either competitor) inhibited iron absorption. To measure transport rates of iron that was absorbed inside ferritin, rat intestinal segments ex vivo were perfused with radiolabeled ferritin and compared to perfusion with ferric nitrilotriacetic (Fe-NTA), a well-studied form of chelated iron. Intestinal transport of iron absorbed inside exogenous ferritin was 14.8% of the rate measured for iron absorbed from chelated iron. In the steady state, endogenous enterocyte ferritin contained >90% of the iron absorbed from Fe-NTA or ferritin. We found that ferritin is a slow release source of iron, readily available to humans or animals, based on RBC iron incorporation. Ferritin iron is absorbed by a different mechanism than iron salts/chelates or heme iron. Recognition of a second, nonheme iron absorption process, ferritin endocytosis, emphasizes the need for more mechanistic studies on ferritin iron absorption and highlights the potential of ferritin present in foods such as legumes to contribute to solutions for global iron deficiency.
General note
Artículo de publicación ISI
Patrocinador
NIH DK20251 CHORI Foundation Fondecyt-Chile 1050068 Hildegard-Grunow-Foundation
Identifier
URI: https://repositorio.uchile.cl/handle/2250/124015
DOI: DOI: 10.3945/jn.111.145854
Quote Item
JOURNAL OF NUTRITION Volume: 142 Issue: 3 Pages: 478-483 Published: MAR 2012
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account