Adolescent Metabolic Syndrome Risk Is Increased with Higher Infancy Weight Gain and Decreased with Longer Breast Feeding
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Khuc, Kim
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Adolescent Metabolic Syndrome Risk Is Increased with Higher Infancy Weight Gain and Decreased with Longer Breast Feeding
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Abstract
Background. Prevalence of the metabolic syndrome is increasing in pediatric age groups worldwide. Meeting the criteria for the
metabolic syndrome puts children at risk for later cardiovascular and metabolic disease. Methods. Using linear regression, we
examined the association between infant weight gain from birth to 3 months and risk for the metabolic syndrome among 16- to
17-year-old Chilean adolescents (n = 357), accounting for the extent of breastfeeding in infancy and known covariates including
gender, birth weight, and socioeconomic status. Results. Participants were approximately half male (51%), born at 40 weeks of
gestation weighing 3.5 kg, and 48% were exclusively breastfed for ≥ 90 days. Factors independently associated with increased risk
of metabolic syndrome in adolescence were faster weight gain in the first 3 months of life (B = 0.16, P < 0.05) and male gender
(B = 0.24, P < 0.05). Breastfeeding as the sole source of milk for ≥ 90 days was associated with significantly decreased risk of
metabolic syndrome (B = −0.16). Conclusion. This study adds to current knowledge about early infant growth and breastfeeding
and their long-term health effects.
Patrocinador
The project was supported by grants from the National
Heart, Lung, and Blood Institute (R01HL088530, PI: S.
Gahagan) and the National Institute of Child Health &
Human Development (R01HD14122 and R01HD33487, PI:
B. Lozoff).
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International Journal of Pediatrics Volume 2012, Article ID 478610, 6 pages
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