Dendritic Cells and Toll-Like Receptors 2 and 4 in the Ileum of Crohn's disease patients
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2008-07Metadata
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Silva, Manuel A.
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Dendritic Cells and Toll-Like Receptors 2 and 4 in the Ileum of Crohn's disease patients
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Abstract
We investigated myeloid-dendritic cell (DC)
marker and Toll-like receptor (TLR)-2 and 4 distributions
in ileal samples from Crohn’s disease (CD) patients
(n = 14) and controls (n = 13). In controls, no TLR-2+
cells were observed, and higher numbers of TLR-4+ and
DC-SIGN+ cells (P\0.01) were detected in ileal samples
when compared versus colonic tissues. In non-inflamed CD
ileum, TLR-4+ and DC-SGN+ cells were depleted from
superficial areas of the villus, and a significant CD1a+ cell
infiltration (P\0.01) was observed when compared to
ileal controls and non-inflamed colonic CD samples. In
inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+ and few
TLR-4+DC-SIGN+ cells were detected as well as CD83
depletion. No correlation between TLR-2 and DC markers
was detected in CD samples. A unique distribution of
myeloid-DC markers characterized the CD ileum. Also, the
presence of significant amounts of ileal CD1a+ cells may
provide a relevant DC-mediated mechanism for antigen
recognition in the pathogenesis of CD.
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DIGESTIVE DISEASES AND SCIENCES, Volume: 53, Issue: 7, Pages: 1917-1928, 2008
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