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Biblioteca Digital - Universidad de Chile
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Human respiratory syncytial virus genomic and antigenic variants isolated in two hospitals during one epidemic, in Santiago, Chile

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2008-07
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Luchsinger Farías, Vivian
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Human respiratory syncytial virus genomic and antigenic variants isolated in two hospitals during one epidemic, in Santiago, Chile
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Author
  • Luchsinger Farías, Vivian;
  • Elgueta Noy, Andrea;
  • Avendaño, Luis Fidel C.;
Abstract
Background: Human respiratory syncytial virus (HRSV) is a major cause of severe lower respiratory tract infection (LRI) in children. Distinct variants of the viruses have been described. Objective: The objective was to compare the antigenic and genetic variability of HRSV strains recovered from infants admitted to two hospitals during one epidemic in a big city. Study design: We analyzed nasopharyngeal aspirates from 201 infants admitted for LRI to two hospitals during 2002 in Santiago, Chile. The analyses were carried out using a panel of monoclonal antibodies against G glycoprotein epitopes (EIA) and RFLP for N and G genes. Results: No differences in HRSV groups A/B and in N patterns distribution were observed among both hospitals. On the contrary, antigenic and genetic G patterns displayed a wide diversity of strains circulating during one epidemic, in one big city. Conclusions: RSV variability assessment depended rather on the tool used for analysis than on the geographical location.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/128398
DOI: 10.1016/j.jcv.2008.03.024
ISSN: 1386-6532
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JOURNAL OF CLINICAL VIROLOGY Volume: 42 Issue: 3 Pages: 260-263 Published: JUL 2008
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