About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Medicina
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Medicina
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Changes in Bone Mineral Density, Body Composition and Adiponectin Levels in Morbid Obese Patients after Bariatric Surgery

Artículo
Thumbnail
Open/Download
Icon133621_C11_Article1.pdf (138.5Kb)
Publication date
2008
Metadata
Show full item record
Cómo citar
Carrasco, Fernando
Cómo citar
Changes in Bone Mineral Density, Body Composition and Adiponectin Levels in Morbid Obese Patients after Bariatric Surgery
.
Copiar
Cerrar

Author
  • Carrasco, Fernando;
  • Ruz, Manuel;
  • Rojas Mondaca, Pamela;
  • Csendes Juhasz, Attila;
  • Rebolledo Acevedo, Annabella;
  • Codoceo, Juana;
  • Inostroza Escobar, Jorge;
  • Basfi-fer Obregón, Karen;
  • Papapietro Vallejo, Karin;
  • Rojas Caro, Jorge;
  • Pizarro Aguirre, Fernando;
  • Ordóñez Pizarro, Fernando;
Abstract
Introduction Gastric bypass surgery (GBP) is increasingly used as a treatment option in morbid obesity. Little is known about the effects of this surgery on bone mineral density (BMD) and the underlying mechanisms. To evaluate changes on BMD after GBP and its relation with changes in body composition and serum adiponectin, a longitudinal study in morbid obese subjects was conducted. Methods Forty-two women (BMI 45.0±4.3 kg/m2; 37.7± 9.6 years) were studied before surgery and 6 and 12 months after GBP. Percentage of body fat (%BF), fat-free mass (FFM), and BMD were measured by dual-energy X-ray absorptiometry and serum adiponectin levels by RIA. Results Twelve months after, GBP weight was decreased by 34.4±6.5% and excess weight loss was 68.2±12.8%. Significant reduction (p<0.001) in total BMD (−3.0± 2.1%), spine BMD (−7.4±6.8%) and hip BMD (−10.5± 5.6%) were observed. Adiponectin concentration increased from 11.4±0.7 mg/L before surgery to 15.7±0.7 and 19.8± 1.0 at the sixth and twelfth month after GBP, respectively (p<0.001). Thirty-seven percent of the variation in total BMD could be explained by baseline weight, initial BMD, BF reduction, and adiponectin at the twelfth month (r 2= 0.373; p<0.001). Adiponectin at the twelfth month had a significant and positive correlation with the reduction of BMD, unrelated to baseline and variation in body compo- sition parameters (adjusted correlation coefficient: r=0.36). Conclusion GBP induces a significant BMD loss related with changes in body composition, although some meta- bolic mediators, such as adiponectin increase, may have an independent action on BMD which deserves further study.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/128482
DOI: DOI 10.1007/s11695-008-9638-0
Quote Item
OBES SURG
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account