Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia
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2002Metadata
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Santolaya de Pablo, María Elena
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Prospective Evaluation of a Model of Prediction of Invasive Bacterial Infection Risk among Children with Cancer, Fever, and Neutropenia
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Abstract
A risk prediction model for invasive bacterial infection (IBI) was prospectively evaluated among children
presenting with cancer, fever, and neutropenia. The model incorporated assessment of 5 previously identified
risk factors: serum level of C-reactive protein (CRP) 90 mg/L, hypotension, identification of relapse of
leukemia as the cancer type, platelet count of 50,000 platelets/mm3, and recent receipt of chemotherapy [16].
Children were uniformly evaluated at enrollment and were classified as having high or low risk for IBI according
to a model that considers the number and type of variables present. Of the 263 febrile episodes evaluated
during a 17-month period, 140 (53%) were in IBI-positive children. The sensitivity, specificity, and positive
and negative predictive values of the model were 92%, 76%, 82%, and 90%, respectively. Identification of these
5 risk factors during the first 24 h of hospitalization was helpful in discriminating between children with a
high or low risk for IBI.
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Financial support: Proyecto FONDECYT grant 1000680.
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URI: https://repositorio.uchile.cl/handle/2250/128733
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Clinical Infectious Diseases 2002; 35:678–83
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