Salivary Urease and ADS Enzymatic Activity as Endogenous Protection against Dental Caries in Children
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Moncada Cortés, Gustavo
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Salivary Urease and ADS Enzymatic Activity as Endogenous Protection against Dental Caries in Children
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Abstract
The aim of this cross sectional study was to evaluate the ureolytic and arginolytic activities of
saliva in children and associate them with their caries status. Study design: 65, 8 year old
children, were randomly selected. The ureolytic and arginolytic activity of non stimulated saliva
was studied and associated with DMFT and dmft index. Saliva of children were sampled under
fasting conditions; Children refrained from any oral hygiene procedures during the 12 hours that
preceded the sample collection. Caries activity was scored and divided in 3 groups: Group A:
Index zero: without lesions; Group B: Moderate Index: I to 3 enamel caries lesions; and Group
C: High Index: more than 4 dentin caries lesions. Results: DMFT scores were moderate: 0.4(+/-
0.79) and dmft: 2.78(+/- 2.45). Results expressed in mu mol/min/mg/protein, for urease activity
were statistically significant (p=0.048): Group A= 0.69 (+/- 0.7); Group B= 0.45 ( +/- 0.43); and
Group C= 0.39 (+/- 0.55). The arginine deiminase activity was not statistically significant
(p=0.16): Group A= 2.53 (+/- 1.42), Group B= 2.31 (+/- 1.57) and Group C= 1.97 (+/- 2.0).
Conclusion: Higher levels of ureolytic (statistically significant) and arginolytic activity (trend) in
saliva were associated with lower DMFT/dmft scores in 8 year old children. There was a higher
production of ammonia from the arginine deiminase system than the urease enzyme in saliva
(p>0.05).
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Volumen: 39 Número: 4 Sum 2015
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