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Mycophenolate Mofetil Therapy in Refractory Inflammatory Eye Disease

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2016
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Cuchacovich Turteltaub, Miguel
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Mycophenolate Mofetil Therapy in Refractory Inflammatory Eye Disease
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Author
  • Cuchacovich Turteltaub, Miguel;
  • Solanes, Federica;
  • Pérez, Claudio;
  • Verdaguer, Juan Ignacio;
  • Verdaguer, Juan;
  • Castiglione, Enzo;
  • Carpentier, Cristian;
  • Traipe, Leonidas;
  • Villarroel, Francisco;
Abstract
Purpose: To study the efficacy and incidence of treatment-related side effects of mycophenolate mofetil (MMF) therapy in patients with noninfectious inflammatory eye diseases. Methods: Retrospective cohort study of 27 Chilean patients treated for noninfectious inflammatory eye diseases using MMF therapy over a 10-year period. Main outcome measures were: ability to control ocular inflammation and to taper prednisone to 10mg daily (treatment success); incidence of treatment-related side effects. Results: The proportion of patients with sustained control of inflammation was 81.48% at 6 months. Additionally 55.56% and 22.22% of patients succeeded in tapering their prednisone to 5-10mg/day and <5mg/day, at 6 months. Two patients developed a neoplasia during MMF therapy; however, this cohort is too small to interpret the significance of this relation to MMF treatment. Conclusions: MMF seems to be an effective corticosteroid-sparing agent with an acceptable safety profile.
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URI: https://repositorio.uchile.cl/handle/2250/138478
DOI: DOI: 10.1089/jop.2015.0044
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Journal of Ocular Pharmacology and Therapeutics Volumen: 32 Número: 1 Páginas: 55-61 (2016)
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