Osseointegration properties of titanium dental implants modifiedwith a nanostructured coating based on ordered porous silicaand bioactive glass nanoparticles
Artículo
Publication date
2016Metadata
Show full item record
Cómo citar
Covarrubias Gallardo, Cristián
Cómo citar
Osseointegration properties of titanium dental implants modifiedwith a nanostructured coating based on ordered porous silicaand bioactive glass nanoparticles
Author
Abstract
The fabrication of a nanoporous silica coating loaded with bioactive glass nanoparticles (nBG/NSC) on titanium dental implant surface and its in vitro and in vivo evaluation is presented. The coating was produced by a combined sol-gel and evaporation induced self-assembly process. In vitro bioactivity was assessed in simulated body fluid (SBF) and investigating the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). A rat tibial model was employed to analyze the bone response to nBG/NSC-modified titanium implant surface in vivo.
The nBG/NSC coating was confirmed at nano level to be constituted by a highly ordered nanoporous silica structure. The coating nanotopography in conjunction with the bioactivity of the BG particles accelerate the in vitro apatite formation and promote the osteogenic differentiation of hBMSCs in absence of osteogenic supplements. These properties accelerate the formation of bone tissue in the periphery of the implant after 3 weeks of implantation. Backscattered scanning electron microscopy images revealed the presence of gaps and soft tissue in the unmodified implant after 6 weeks, whereas the nBG/NSC-modified implant showed mature bone in intimate contact with the implant surface. The nBG/NSC coating appears promising for accelerating the osseointegration of dental implants.
General note
Artículo de publicación ISI
Patrocinador
National Commission for Scientific and Technological Research (CONICYT) of the Government of Chile through FONDECYT Project
11100495; U-Redes Project, Nanotechnology for Biomedical Applications Network (NanoBioMat), University of Chile
Identifier
URI: https://repositorio.uchile.cl/handle/2250/138936
DOI: DOI: 10.1016/j.apsusc.2015.12.022
Quote Item
Applied Surface Science 363 (2016) 286–295
Collections
The following license files are associated with this item: