Trombolisis intravenosa en accidente cerebro vascular isquémico agudo en un hospital público de Chile: Análisis prospectivo de 54 casos
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2016Metadata
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Guevara O., Carlos
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Trombolisis intravenosa en accidente cerebro vascular isquémico agudo en un hospital público de Chile: Análisis prospectivo de 54 casos
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Abstract
Background: Intravenous thrombolysis with recombinant tissue plasminogen
activator (rt-PA) reduces disability in patients with ischemic stroke. However, its
implementation in Chilean public general hospitals has been slow and faces some
difficulties. Aim: To analyze the results of an intravenous thrombolysis protocol
implementation in a public general hospital. Material and Methods: During a
lapse of 28 months a standardized protocol for intravenous thrombolysis implemented
in the emergency room of a public hospital, was prospectively evaluated.
Fifty four patients with ischemic stroke were treated and assessed three months
later as outpatients. Results: At three months of follow-up, 66.4% of patients
subjected to thrombolysis had a favorable evolution, defined as having 0 to 1
points in the modified Rankin scale. Intracerebral hemorrhage rate was 11.1%,
including 5.5% of symptomatic intracerebral hemorrhage. Four percent of
patients had systemic bleeding complications after thrombolysis. The mortality
rate was 14.8%. Conclusions: The success rates, mortality, and complications
rate were comparable to the results obtained in international studies, despite of
the absence of a stroke unit to manage stroke and its complications.
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Rev Med Chile 2016; 144: 442-450
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