Highly stereoselective and catalyst-free synthesis of annulated tetrahydropyridines by intramolecular imino-Diels-Alder reaction under microwave irradiation in water

Abstract

A microwave-assisted method for the synthesis of tetracyclic tetra-hydropyridines via an intramolecular imino-Diels-Alder reaction in water is reported. The reaction proceeds under catalyst-free conditions and shows excellent stereoselectivity