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Thyroid hormone therapy and procurement of livers from brain-dead donors

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2016
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Novitzky, Dimitri
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Thyroid hormone therapy and procurement of livers from brain-dead donors
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  • Novitzky, Dimitri;
  • Mi, Zhibao;
  • Videla Cabrera, Luis;
  • Collins, Joseph F.;
  • Cooper, David K. C.;
Abstract
Hormonal therapy to brain-dead potential organ donors remains controversial. A retrospective study was carried out of hormonal therapy on procurement of organs in 63,593 donors in whom information on T-3/T-4 therapy was available. In 40,124 donors, T-3/T-4 and all other hormonal therapy was recorded. The percentages of all organs procured, except livers, were greater in T-3/T-4-treated donors. Nevertheless, if T-3/T-4 therapy had been administered to the donor, liver transplantation was associated with significantly increased graft and recipient survival at 1 month and 12 months. The potential reasons for the lack of effect of T-3/T-4 therapy on the number of livers procured are discussed.
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URI: https://repositorio.uchile.cl/handle/2250/142618
DOI: 10.3109/07435800.2015.1111902
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Endocrine Research. Volumen: 41 Número: 3 Páginas: 270-273
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